The behavioral change of locomotor activity in a kaolin-induced hydrocephalus rat model: Evaluation of the effect on the dopaminergic system with progressive ventricle dilatation
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Acknowledgement
This research was supported by a grant (no. 10031270) from Developmental Program for Korea Industrial Innovation Technology funded by the Ministry of Knowledge and Economy, the Republic of Korea.
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Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus
2014, Neuroscience LettersCitation Excerpt :All procedures conformed to the guidelines of the animal welfare laws in China, the United Kingdom, and the United States and the local animal welfare committee. We used an injection of kaolin into the cisterna magna to establish the communicating hydrocephalus rat model [10,11]. Rats in each group were deeply anesthetized by injection of chloral hydrate (40 mg/100 g) into the abdominal region.
Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats
2014, International Journal of Developmental NeuroscienceCitation Excerpt :While VM can be induced by a number of different processes, one way to induce it mechanically in animals is by kaolin injection in the cisterna magna. Kaolin-induced VM can cause a loss of dopamine neurons in the substantia nigra in adult rats and significantly reduce levels of other monoamines (Chovanes et al., 1988; Hwang et al., 2009; Lovely et al., 1989). These decreases in monoamines are concurrent with reductions in locomotor activity beginning 3 days after treatment and becoming more severe by 4 weeks (Hwang et al., 2009).
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