Electrophysiological actions of orexins on rat suprachiasmatic neurons in vitro
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Acknowledgements
This work was funded by project grants from the BBSRC to HDP. We thank Elizabeth Greene and Dr. Helen Reed for technical assistance.
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The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target
2021, Neuroscience LettersOrexin A excites the rat olivary pretectal nucleus via OX<inf>2</inf> receptor in a daily manner
2021, Brain ResearchCitation Excerpt :Finally, we propose a coupling of orexinergic and retinal information on the same OPN neurons, which respond to both OXA and PAC1 receptor agonist. The modulation of neuronal activity in the subcortical visual system by orexins has been proposed before, for such areas as the lateral geniculate nucleus (LGN; all three parts) (Chrobok et al., 2021b; Chrobok et al., 2017; Chrobok et al., 2016; Orlowska-Feuer et al., 2019; Palus et al., 2015; Pekala et al., 2011), the SCN (Belle et al., 2014; Belle et al., 2017; Brown et al., 2008), or recently for the superior colliculus (Chrobok et al., 2021a). The functional connection between these two systems has also been strengthened by reports on orexin action in the retina (Qiao et al., 2017; Zhang et al., 2018) and the primary visual cortex (Bayer, 2004).
Distinct feedback actions of behavioural arousal to the master circadian clock in nocturnal and diurnal mammals
2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Other structures could also transmit light information to the SCN indirectly. For example, the lateral hypothalamic area (LH) is also a target of the RHT (Hattar et al., 2006) and the arousal-promoting orexin neurons in the LH project to the immediate vicinity of the SCN (McGranaghan and Piggins, 2001; Brown et al., 2008). The downstream signaling of the photic pathways induces acute expression of several immediate early genes, such as c-fos, and the clock genes Per1 and Per2 (Kornhauser et al., 1990; Albrecht et al., 1997; Shigeyoshi et al., 1997).
Sleep architecture and homeostasis in mice with partial ablation of melanin-concentrating hormone neurons
2016, Behavioural Brain ResearchCitation Excerpt :Indeed, they receive direct as well as indirect inputs from the SCN [39–41] and reciprocally send efferents to the SCN [12,16,42,43]. Additionally, orexin and SCN neurons may be involved in a reciprocal inhibitory loop to which MCH neurons could be linked [44–46]. MCH neurons could indeed inhibit the SCN through activation of MCH-R1 receptors, thus repressing the facilitation of SCN-driven PS entry [38].
Organization of the orexin/hypocretin system in the brain of two basal actinopterygian fishes, the cladistians Polypterus senegalus and Erpetoichthys calabaricus
2014, PeptidesCitation Excerpt :Cholinergic cells have not been identified in the basal forebrain of Polypterus and, since they are not present in agnathans and exist in all other actiniopterygian and sarcopterygian vertebrates, this type of interaction would have appeared later in evolution [80]. The presence of a high OX-ir innervation in the suprachiasmatic nucleus is a general feature observed in all vertebrates [30,37,61,78,79,87,90,127], and this innervation can alter suprachiasmatic neuronal activity and influence the transmission of information to other brain regions [15,67]. Only few OX-ir fibers reach the median eminence of cladistians, suggesting a possible function in neuroendocrine regulation.
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These authors contributed equally to this study.