ReviewPersistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication
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Keywords
Behavior
Cognition
Diisopropylfluorophosphate
Electroencephalography
Microgliosis
Persistent effects
Preclinical model
Reactive astrogliosis
Spontaneous recurrent seizures
Sublethal toxicity
Abbreviations
CounterACT
Countermeasures Against Chemical Threats program
DFP
diisopropylfluorophosphate
EEG
electroencephalography
EPM
elevated plus maze
GFAP
glial fibrillary acidic protein
IBA-1
ionized calcium binding adaptor molecule 1
NIH
National Institutes of Health
3-NT
3-nitrotyrosine
OP
organophosphate
2-PAM
2-pralidoxime
PBS
phosphate-buffered saline
PET
positron emission tomography
SD
standard deviation
SE
status epilepticus
SEM
standard error of the mean
SRS
spontaneous recurrent seizures
TSPO
18 kD mitochondrial membrane translocator protein
VEH
vehicle
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These authors contributed equally to this work.
© 2019 Elsevier Inc.