Synthesis of Dy-Y co-substituted manganese‑zinc spinel nanoferrites induced anti-bacterial and anti-cancer activities: Comparison between sonochemical and sol-gel auto-combustion methods

https://doi.org/10.1016/j.msec.2020.111186Get rights and content

Highlights

  • (DyY-MnZn NSFs) were constructed via citrate sol-gel combustion and ultrasonic irradiation routes

  • X-ray diffraction proved the construction of both spinel ferrites and hematite phase in DyY-MnZn NSFs.

  • The saturation and remanent magnetizations are greatly larger in NPs synthesized ultrasonically than those prepared by using sol-gel approach.

  • The biological applications of DyY-MnZn NSFs showed anti-cancer and anti-bacterial (Escherichia coli and Staphylococcus aureu) activities.

Abstract

This study described the beneficial properties of ultrasonic irradiation approach to synthesize the spinel-type Dy-Y co-substituted Mn-Zn nanospinel ferrites (NSFs). We have used two different approaches like citrate sol-gel combustion and ultrasonic irradiation routes to produced series of Mn0.5Zn0.5Fe2-2x(DyxYx)O4 (0.0 ≤ x ≤ 0.05) NSFs (DyY-MnZn NSFs). The structure and morphology of NSFs X-was examined by using XRD, EDX, SEM and TEM methods. We have found that spinel ferrites and hematite phase in DyY-MnZn NSFs produced by citrate sol-gel, while DyY-MnZn NSFs created by ultrasonic irradiation contain a pure phase of spinel ferrite. TEM analysis revealed the spherical nanoparticles with fairly uniform size. We have also analyzed the biological applications of DyY-MnZn NSFs prepared by both methods (ultrasonication and sol-gel) by examining their anti-cancer and anti-bacterial (Escherichia coli and Staphylococcus aureu) activities. We have found that both methods produced inhibitory actions on colon cancer cells (HCT-116) and bacterial cells, whereas, no inhibitory action was observed when examined on normal and non-cancerous cells (HEK-293).

Keywords

Spinel ferrites
Sonochemical synthesis
Sol-gel route
Magnetic properties
Anticancer-antibacterial activity

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