Molecular Cell
Volume 42, Issue 1, 8 April 2011, Pages 23-35
ArticleOncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
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Graphical Abstract
Highlights
► Oncogenic H-RasV12 can promote cell death with features of autophagy ► H-RasV12 induced upregulation of the BH3-only protein, Noxa, as well as Beclin-1 ► Ras-induced Noxa displaced the Bcl-2 family member, Mcl-1, from Beclin-1 ► Autophagic cell death may limit the transforming potential of oncogenic forms of Ras
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Present address: Children's Cancer Centre, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3052, Australia
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