Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development
Section snippets
Results and discussion
Cerebral Cavernous Malformation (CCM) is vascular malformation histologically characterized mainly of abnormally enlarged capillary cavities lined by endothelial cells without intervening brain parenchyma (Russel and Rubinstein, 1989). Clinical manifestations include cerebral hemorrhages and seizures. CCM occurs both as a sporadic (80% cases) and familial autosomal dominant condition (20% cases). Familial cases are characterized by the presence of multiple cerebral lesions, which may be
Experimental procedures
The procedures used in this study have been previously described (Sibony et al., 1995, Denier et al., 2002).
Acknowledgements
We thank Anne Joutel for helpful discussion and Valérie Domenga for technical advice. NP is a recipient from Fondation Lefoulon-Delalande fellowship. This work was supported by INSERM, GIS Maladies Rares (AO 2002-2004) and Programme Hospitalier de Recherche Clinique Régional (PHRC AOR03031).
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