Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium
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Highlights
► Undifferentiated spermatogonia differentiate periodically in mouse seminiferous tubules. ► Meiotic and haploid germ cells regulate the local retinoic acid (RA) metabolism. ► The increased RA triggers the differentiation of undifferentiated spermatogonia. ► RA also resets the functional cycle of somatic Sertoli cells. ► Thus, RA metabolism links the germ cell differentiation and Sertoli cell cycle.
Keywords
Spermatogonia
Retinoic acid
Seminiferous epithelial cycle
Sertoli cells
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