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Integrating the negative psychotic symptoms in the high risk criteria for the prediction of psychosis

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Cited by (20)

  • Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome

    2019, Schizophrenia Research
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    At the cross-sectional level, the prevalence and factor structure of NS as well as their severity and prevalence in relation to the presence of UHR criteria were examined. Based on findings in other UHR samples (Fusar-Poli and Borgwardt, 2007; Piskulic et al., 2012), we expected more frequent and severe NS in 22q11DS participants meeting UHR criteria. At the longitudinal level, we examined the course of NS over a 32-month interval (i.e. presence and severity of NS at baseline and follow-up) in relation to baseline and change in general functioning, persistence/onset of UHR condition at follow-up, and transition to psychosis at follow-up.

  • Adolescent psychosis risk symptoms predicting persistent psychiatric service use: A 7-year follow-up study

    2019, European Psychiatry
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    Of note, not only positive risk symptoms were predictive of more persistent service use, but negative, general and disorganized risk symptoms were equally predictive. The role of negative symptoms as psychosis risk symptoms is somewhat underrepresented [32] as the ultra-high risk and clinical high-risk criteria are based on positive symptoms only. However, studies show that the negative symptom cluster also is predictive of psychosis [16] and poorer functioning [17].

  • Brain development in adolescents at ultra-high risk for psychosis: Longitudinal changes related to resilience

    2016, NeuroImage: Clinical
    Citation Excerpt :

    In addition, the criterion of ‘transition to psychosis’ has been criticized as a measure to identify which individuals will have a truly poor clinical outcome: the threshold for transition is essentially arbitrary and is based entirely on positive symptoms (Fusar-Poli et al., 2013; Ziermans et al., 2014). There is increasing evidence that negative symptoms and the level of cognitive and social functioning are equally important for the long-term outcome of UHR individuals (Fusar-Poli and Borgwardt, 2007; Carrión et al., 2013; Fusar-Poli et al., 2013). Moreover, some individuals may develop psychosis before going on to recover completely, while some individuals who do not develop psychosis may have worse outcomes (Yung et al., 2010; Fusar-Poli and Van Os, 2013; Cotter et al., 2014; de Wit et al., 2014).

  • Outreach and support in South London (OASIS), 2001-2011: Ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis

    2013, European Psychiatry
    Citation Excerpt :

    Even less is known about the outcome among the group of ARMS subjects who do not convert to psychosis as a few studies only provided characteristics of those subjects who did not develop psychosis [64]. At the psychopathological level, some discussion is emerging around the fact that the CAARMS transition criteria are too weighted towards positive psychotic symptoms [23]. As a result, the ARMS subjects who develop severe negative symptoms or functional impairments (but not severe positive symptoms) can still be categorized as not having made a transition [81].

  • Neuroimaging studies of the early stages of psychosis: A critical review

    2008, European Psychiatry
    Citation Excerpt :

    Consequently, existing diagnostic categories may not really fit a large proportion of individuals with psychotic experiences, especially in the prodromal phase. For example, high risk subjects presenting only with negative psychotic symptoms may be excluded from current high-risk studies as some inclusion criteria for the ARMS are weighted towards positive symptoms [23]. These observations are mirrored by the observation that criteria applied to detect individuals with a significantly increased risk of psychosis within the schizophrenia spectrum are only validated on clinical populations [46].

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