EditorialOn the role of CEACAM1 in cancer
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None declared.
References (30)
- et al.
Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is associated with increased angiogenic potential in non-small cell lung cancer
Lung Cancer
(2008) CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
Curr Opin Cell Biol
(1997)- et al.
Homotypic and heterotypic Ca++-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface
Biochem Biophys Res Commun
(1992) - et al.
Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation
Exp Cell Res
(2005) - et al.
Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells
Blood
(2005) - et al.
CEACAM1 enhances invasion and migration of melanocytic and melanoma cells
Am J Pathol
(2004) - et al.
Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1
Blood
(2007) - et al.
Pro-angiogenic signaling by the endothelial presence of CEACAM1
J Biol Chem
(2005) - et al.
The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues
Cancer Res
(1993) - et al.
Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas
Proc Natl Acad Sci USA
(1993)
Decreased expression of biliary glycoprotein in hepatocellular carcinomas
Int J Cancer
Expression of biliary glycoprotein (CD66a) in normal and malignant breast epithelial cells
Anticancer Res
Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition
Hum Pathol
CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer
Oncogene
Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer
Cancer Res
Cited by (34)
Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)
2020, Biochemistry and Biophysics ReportsCitation Excerpt :For example, CEACAM1 is dysregulated in several tumors compared with normal tissues, such as colorectal, prostatic, and breast cancers, indicating that CEACAM1 functions as a tumor suppressor [13–15]. However, CEACAM1 is upregulated and promotes tumor progression in several tumors, such as melanoma and lung cancer [16,17], and the upmodulation of CEACAM1 increases microvascular density and correlates with the development of distant metastases in non-small-cell lung carcinoma [12], suggesting that CEACAM1 is oncogenic. In this study, we examined the development of VM using common in vitro methods [18–20].
The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells
2017, Cell ReportsCitation Excerpt :The tumor-specific stem cell population was characterized by low levels of Ceacam1, which is a type I transmembrane protein with multiple biological functions (Beauchemin and Arabzadeh, 2013). It has been reported that Ceacam1 is downregulated in several human cancers, including colon cancer (Nittka et al., 2004; Obrink, 2008), and its product functions as a growth inhibitor in Apc-mutated mice (Leung et al., 2008). These findings are consistent with our observation that the downregulation of Ceacam1 can serve as a marker for tumor-initiating cells.
CEACAM1 Promotes Melanoma Cell Growth through Sox-2
2014, Neoplasia (United States)Citation Excerpt :Remarkably, homozygosity to these alleles conferred increased risk to melanoma with relative risk of 1.35 (95% CI = 1.01-1.81; P = .05). Expression analysis in various types of cancer shows that CEACAM1 is overexpressed in some malignancies, such as melanoma, lung cancer, and thyroid carcinoma, whereas it is downregulated in colon, prostate, endometrial, and breast cancers [35]. CEACAM1 exerts tumor-suppressive effects in colon [21], prostate [22], and breast cancer cells [36], which could explain its loss in these types of cancers.
Amelogenins : Multi-functional enamel matrix proteins and their binding partners
2011, Journal of Oral BiosciencesStructure of the N-terminal dimerization domain of CEACAM7
2015, Acta Crystallographica Section:F Structural Biology Communications