Elsevier

Lung Cancer

Volume 60, Issue 3, June 2008, Pages 309-312
Lung Cancer

Editorial
On the role of CEACAM1 in cancer

https://doi.org/10.1016/j.lungcan.2008.03.020Get rights and content

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Conflict of interest

None declared.

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    • Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)

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      For example, CEACAM1 is dysregulated in several tumors compared with normal tissues, such as colorectal, prostatic, and breast cancers, indicating that CEACAM1 functions as a tumor suppressor [13–15]. However, CEACAM1 is upregulated and promotes tumor progression in several tumors, such as melanoma and lung cancer [16,17], and the upmodulation of CEACAM1 increases microvascular density and correlates with the development of distant metastases in non-small-cell lung carcinoma [12], suggesting that CEACAM1 is oncogenic. In this study, we examined the development of VM using common in vitro methods [18–20].

    • The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells

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      The tumor-specific stem cell population was characterized by low levels of Ceacam1, which is a type I transmembrane protein with multiple biological functions (Beauchemin and Arabzadeh, 2013). It has been reported that Ceacam1 is downregulated in several human cancers, including colon cancer (Nittka et al., 2004; Obrink, 2008), and its product functions as a growth inhibitor in Apc-mutated mice (Leung et al., 2008). These findings are consistent with our observation that the downregulation of Ceacam1 can serve as a marker for tumor-initiating cells.

    • CEACAM1 Promotes Melanoma Cell Growth through Sox-2

      2014, Neoplasia (United States)
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      Remarkably, homozygosity to these alleles conferred increased risk to melanoma with relative risk of 1.35 (95% CI = 1.01-1.81; P = .05). Expression analysis in various types of cancer shows that CEACAM1 is overexpressed in some malignancies, such as melanoma, lung cancer, and thyroid carcinoma, whereas it is downregulated in colon, prostate, endometrial, and breast cancers [35]. CEACAM1 exerts tumor-suppressive effects in colon [21], prostate [22], and breast cancer cells [36], which could explain its loss in these types of cancers.

    • Structure of the N-terminal dimerization domain of CEACAM7

      2015, Acta Crystallographica Section:F Structural Biology Communications
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