Guest editorialSignificance of AF4-MLL reciprocal fusion in t(4;11) leukemias?
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Cited by (5)
Revisiting the biology of infant t(4;11)/MLL-AF4<sup>+</sup> B-cell acute lymphoblastic leukemia
2015, BloodCitation Excerpt :Therefore, AF4-MLL seems capable of inducing ALL in mice without the requirement of MA4, suggesting that the reciprocal protein is the initiating event of MA4+ leukemia.83 However, controversy about the role of AF4-MLL as an oncogenic initiating event exists because AF4-MLL is not expressed in one third of the patients112 and by studies on t(4;11) cell lines showing that they display addiction to MA4 but not to AF4-MLL.113,114 However, a transient silent interfering RNA-mediated knockdown of AF4-MLL was not sufficient to downregulate the AF4-MLL fusion protein, likely due to the stability of the AF4-MLL protein.
The promise and failures of epigenetic therapies for cancer treatment
2014, Cancer Treatment ReviewsCitation Excerpt :For example, aberrant H3K9 methylation by KMT1C has been associated with chromosomal instability and epithelial to mesenchymal transition, with recurrent translocation and/or mutation of KMT2, KMT3A, and KMT6 found in several cancers.151,134 Loss of KMT1 is associated with decreased viability, genomic instability and increase tumor risk in mice.152 In addition, frequent somatic mutation involving the conversion of Tyr to Phe in the active site of KMT6 has been reported in lymphomas.133
MLL-rearranged acute myeloid leukemia: Influence of the genetic partner in allo-HSCT response and prognostic factor of MLL 3′ region mRNA expression
2018, European Journal of HaematologyClassification of mixed-lineage leukemia fusion partners predicts additional cancer pathways
2016, Annals of Laboratory Medicine