Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing

doi:10.1016/j.jpeds.2019.04.058

The Journal of Pediatrics

Volume 212, September 2019, Pages 228-231

https://doi.org/10.1016/j.jpeds.2019.04.058 Get rights and content

An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection.

Keywords

HHV-6

BioFire FilmArray

roseola

Abbreviations

CSF

Cerebrospinal fluid

HHV-6

Human herpesvirus 6

mNGS

Metagenomic next-generation sequencing

PCR

Polymerase chain reaction

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: Supported by National Institutes of Health (1K23AI128069-01), the Charles and Helen Schwab Foundation, the George and Judy Marcus Foundation, and the California Initiative to Advance Precision Medicine. These funding sources had no role in study design or writing of the manuscript and the views expressed are solely those of the authors. The authors declare no conflicts of interest.

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The Journal of Pediatrics

Brief ReportGastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing

Keywords

Abbreviations

Brief Report
Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing