Basic and patient-oriented researchHistomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits
Section snippets
Materials and Methods
Ethical approval was obtained from Selcuk University Faculty of Medicine Department of Experimental Medicine Research and Application Center Ethical Committee.
This experimental study was carried out with 18 5-month-old male New Zealand rabbits weighing 2.2 to 2.8 kg (mean weight, 2.4 ± 0.17 kg). All animals were divided into 2 groups (experimental group and control group).
General anesthesia was achieved via intramuscular injection of 50 mg/kg ketamine and 8 mg/kg xylazine hycloride (Rompun;
Results
One animal was excluded from study because of infection surrounding the pin. No other complications or problems were encountered with the animals during the procedures.
Discussion
Craniofacial bones are different from long bones with regard to their membranous structure and biomechanical condition. For example, long bones bear forces along their anatomical axis whereas the mandible faces strengths perpendicular to its anatomical axis. Additionally, mandible and long bones express different growth and development.10
Bisphosphonates affect bone resorption strongly and have been applied in management of several osteoclast originated bone diseases. Bisphosphonates are
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Investigation of effects of low level laser therapy in distraction osteogenesis
2018, Journal of Stomatology, Oral and Maxillofacial SurgeryCitation Excerpt :To shorten this period, several techniques and biologic materials have been investigated. Calcium sulfate, electrical stimulation, osteoblast like cell transplantation, growth hormone, bone morphogenetic proteins, insulin like growth factor-1 (IGF-1), trombosit-rich-plasma, ultrasound, calcitonine, simvastatine, zoledronic acid, calcium hydroxide, hyperbaric oxygen therapy have been used to stimulate bone callus and to achieve a good quality of bone in a shorter consolidation period [17–30]. The positive effects on low energy level laser bone healing suggests that it may also have biostimulatory role in distraction otoogenesis.
Experimental comparison of the effects of locally administered zoledronic acid and alendronate on the rate of mandibular distraction osteogenesis in dogs
2014, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyEnhancement of bone consolidation in mandibular distraction osteogenesis: A contemporary review of experimental studies involving adjuvant therapies
2013, Journal of Plastic, Reconstructive and Aesthetic SurgeryCitation Excerpt :Bone density was also noted to be improved with this adjuvant therapy. Zoledronic acid is another bisphosphonate that has been studied in MDO experimental models.26,27 Similar to alendronate, both of these studies showed significantly greater BMD and BMC in the treatment groups, suggesting a favorable bone healing effect of this medication.
Effects of alendronate on human osteoblast-like MG63 cells and matrix metalloproteinases
2012, Archives of Oral BiologyCitation Excerpt :The premise of this hypothesis is that the jaw has greater blood supply and higher remodelling rate than other skeleton tissues. In vivo animal experiments have shown that bisphosphonates can suppress normal bone turnover and remodelling, and inhibit bone reparative ability.22,29,30 Osteoblasts and osteoclasts are the two major players in the bone remodelling process and are both affected by bisphosphonates.
This study was supported by Scientific Research Project, Selçuk University, Konya, Turkey.