Clinical articleManagement and Outcome of Patients With Malignant Salivary Gland Tumors
Section snippets
Materials and Methods
The records of all patients with malignant salivary gland tumors presenting for treatment at Legacy Emanuel Hospital and Health Center (LEHHC) between 1992 and 2002 were retrospectively reviewed. Data were collected from the LEHHC cancer data registry and from individual physician chart notes. Variables collected included age, gender, tumor site, histologic diagnosis, grade, stage, symptoms, treatment, the presence of regional/distant metastasis, margin status, perineural/angiolymphatic
Results
Eighty-five patients met the criteria for inclusion in the study. Thirty-five of these patients were male and 50 were female, ranging in age from 16 to 89 years (mean, 58.6 years). The site of presentation was distributed as follows: parotid (n = 42 [50%]), submandibular gland (n = 8 [9%]), sublingual gland (n = 6 [7%]), and minor salivary glands (n = 29 [34%]) (Fig 1). Mucoepidermoid carcinoma was the most common neoplasm (n = 40 [47%]), followed by adenoid cystic carcinoma (n = 15 [18%]),
Discussion
The management of salivary gland malignancies remains primarily surgical. Refined imaging technology, recognition of the potential benefits of adjuvant radiation therapy, developments in neutron beam therapy, and the introduction of chemotherapeutic regimens have altered the various treatment strategies. Although the effect of radiation therapy was not specifically evaluated in this observational study, combined modality therapy appears to play an important role in the treatment of patients
References (39)
- et al.
Incidence rates of salivary glands tumorsResults from a population-based study
Otolaryngol Head Neck Surg
(1999) - et al.
Carcinoma of the major salivary glands treated by surgery or surgery plus postoperative radiotherapy
Int J Radiat Oncol Biol Phys
(1990) - et al.
Postoperative radiotherapy for malignant tumors of the parotid gland
Int J Radiat Oncol Biol Phys
(1997) - et al.
Neutron versus photon irradiation for unresectable salivary gland tumorsFinal report of an RTOG-MRC randomized clinical trial
Int J Radiat Oncol Biol Phys
(1993) - et al.
Neutron radiotherapy for adenoid cystic carcinoma for minor salivary glands
Int J Radiat Oncol Biol Phys
(1996) - et al.
Malignant tumors of the submandibular salivary glandA 15-year review
Br J Plast Surg
(1998) - et al.
Intraoral minor salivary gland neoplasmA single institution experience of 80 cases
Int J Oral Maxillofac Surg
(2002) - et al.
Prognostic variables in malignant epithelial tumors of the parotid
Int J Radiat Oncol Biol Phys
(1992) - et al.
Postoperative irradiation of minor salivary gland malignancies of the head and neck
Radiother Oncol
(1999) - et al.
Conbined treatment of adenoid cystic carcinoma of the salivary glands
Int J Oral Maxillofac Surg
(2000)
Neck dissection in the treatment of cancer of major salivary glands
Otolaryngol Clin North Am
Health related quality of life after maxillectomyA comparison between prosthetic obturation and free flap
J Oral Maxillofac Surg
Salivary neoplasmsOverview of a 35-year experience with 2807 patients
Head Neck Surg
Carcinoma of major salivary glands
Arch Otolaryngol Head Neck Surg
Recent trends in the incidence of salivary gland cancer
Int J Epidemiol
Malignant tumors of major salivary gland originA matched pair analysis of the role of combined surgery and postoperative radiotherapy
Arch Otolaryngol Head Neck Surg
Parotid gland carcinomaAnalysis of prognostic factors
Ann Otol Rhinol Laryngol
Malignant epithelial parotid gland tumorsAnalysis and results in 65 previously untreated patients
Br J Plast Surg
Outcome of curative management of malignant tumours of the parotid gland
J Otolaryngol
Cited by (212)
Diagnosis and Management of Pathological Conditions
2023, Journal of Oral and Maxillofacial SurgeryAdjuvant radiotherapy in node-negative salivary malignancies of the parotid gland: A multi-institutional analysis
2023, Radiotherapy and OncologyThe impact of interval between surgery and postoperative radiotherapy in major salivary gland carcinoma
2022, Journal of the National Cancer CenterCitation Excerpt :The proportion of adjuvant radiotherapy in patients with and without adverse features were 54%-84.5% and 17%,5 respectively. Radiotherapy following operation can improve local-regional control rate and survival in patients with adverse features, such as positive surgical margin, high-grade tumors, perineural invasion (PNI), T3-4 tumors, and positive lymph nodes.6,7 Despite the lack of prospective studies, postoperative radiotherapy (PORT) is strongly recommended for high-risk cases.
Radiographic-anatomy, natural history and extension pathways of parotid and submandibular gland cancers
2022, Radiotherapy and Oncology