Clinical ResearchHistologic Assessment of Human Pulp Response to Capping with Mineral Trioxide Aggregate and a Novel Endodontic Cement
Section snippets
Material and Methods
This prospective randomized controlled clinical trial was performed in vivo and was approved by the Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran, in 2009, and the protocol was registered at clinical trials.gov (Clinicaltrials.gov ID: NCT01066533). First premolars that were scheduled for extraction for orthodontic reasons were selected. Inclusion criteria included the following: (1) patients who were 15–25 years old; (2) patients with no systemic disease; (3) teeth
Results
The control intact teeth showed normal pulp tissue with no inflammatory cells, with columnar odontoblast cells. A summary of the results is presented in Table 2.
In the NEC group after 2 weeks (group 1), there was fibrous tissue with no calcification at the exposure site in 62.5% of specimens, and only 37.5% showed some evidence of calcified tissues in the fibrous matrix. In 50% of specimens the mean thickness of barrier was 0.1–0.25 mm, and the others were less. In this group, 50% of samples
Discussion
Preserving the vitality of exposed pulp, particularly in immature teeth, is the ultimate goal in vital pulp therapy. Stanley (12) advocated that pulp capping procedures could be performed successfully on asymptomatic carious exposures. Haskell et al (13) proved that asymptomatic carious exposures could survive an average of 12 years after pulp capping. MTA has been introduced with reasonable properties for direct pulp capping such as less inflammation and greater dentinal bridge formation,
Acknowledgments
This study was supported by Vice Chancellor for Research of Mashhad University of Medical Sciences and Endodontic Research Center of Shahid Beheshti University M.C., Tehran, Iran. The authors wish to thank Dr Hamid Jafarazadeh for assistance in preparing this manuscript and D. Saeed Asgary for providing NEC cement.
The authors deny any conflicts of interest.
References (26)
- et al.
Using mineral trioxide aggregate as a pulp-capping material
J Am Dent Assoc
(1996) - et al.
Properties of a new root end filling material
J Endod
(2005) - et al.
The properties of a new endodontic material
J Endod
(2008) - et al.
Comparison of mineral trioxide aggregate’s composition with Portland cements and a new endodontic cement
J Endod
(2009) - et al.
A comparative study of histologic response to different pulp capping materials and a novel endodontic cement
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2008) Pulp capping: conserving the dental pulp—can it be done? is it worth it?
Oral Surg Oral Med Oral Pathol
(1989)- et al.
Direct pulp capping treatment: a long term follow up
J Am Dent Assoc
(1978) - et al.
Evaluation of the tissue reaction to fast endodontic cement (CER) and Angelus MTA
J Endod
(2009) - et al.
Physical and chemical properties of new-generation endodontic materials
J Endod
(2010) - et al.
Histological and scanning electron microscopy assessment of various vital pulp therapy materials
J Endod
(2003)
Histopathological study of dental pulp tissue capped with enamel matrix derivative
J Endod
Pulpal responses following direct pulp capping of healthy dog teeth with dentin adhesive systems
J Dent
Physical and chemical properties of a new root end filling material
J Endod
Cited by (88)
Dental pulp capping nanocomposites
2019, Applications of Nanocomposite Materials in DentistryDirect Pulp Capping: What is the Most Effective Therapy?—Systematic Review and Meta-Analysis
2018, Journal of Evidence-Based Dental PracticeCitation Excerpt :The success rate of tricalcium silicate cements varied between 83% and 100% (average 91.3%), and for MTA cements, it ranged from 86.9% to 100% (94.1% average).40–43 Intense inflammatory response ranged between 9% and 12.5% (mean of 10.7%) in tricalcium silicates and from 9% to 25% (mean of 17%) in MTA cements.42,44 The dentin bridge was completely edged with tricalcium silicate cements ranging from 27.3% to 63.7% (mean of 47%) and from 18.2% and 63.7% (mean of 35.6%) with MTA cements.42–44
Dental pulp capping nanocomposites
2018, Applications of Nanocomposite Materials in DentistryDental Pulp Response to RetroMTA after Partial Pulpotomy in Permanent Human Teeth
2018, Journal of EndodonticsThe effect of dental pulp-capping materials on hard-tissue barrier formation: A systematic review and meta-analysis
2018, Journal of the American Dental Association