Case ReportCedecea davisae bacteremia in a neutropenic patient with acute myeloid leukemia
Introduction
Cedecea are gram negative bacilli and members of the Enterobacteriaceae family that were designated as a separate genus in 1980. Invasive infection with Cedecea species is extremely rare. We present a case of successful treatment of Cedecea davisae bacteremia in an immunocompromised host and present a brief review of the literature.
Section snippets
Case report
A 52 year-old Caucasian male with acute myeloid leukemia (AML) was admitted to the hospital for chemotherapy. On the day of admission, a tunneled catheter was placed in the right internal jugular vein and induction chemotherapy was started with cytarabine, cladaribine and idarubicin. On day nine post-induction, he became neutropenic with an absolute neutrophil count of 710/μl with further decline to 40/μl next day. Prophylactic antibiotics including levofloxacin, fluconazole and valacyclovir
Discussion
Cedecea was first identified to be a new genus in the family enterobacteriacea at the Centers for Disease Control (CDC) and the organism was later named Cedecea from the letters CDC.8 They are more closely related to Serratia but do not hydrolyze gelatin or DNA. The detail biochemical properties of Cedecea have been previously described.8 The genus includes five species.
The organism has been isolated from various clinical specimens including sputum, cutaneous ulcers, oral ulcer, scrotal
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Cited by (18)
Expanding spectrum of opportunistic Cedecea infections: Current clinical status and multidrug resistance
2020, International Journal of Infectious DiseasesCitation Excerpt :The clinical cases summarized in Table 1 indicate the opportunistic nature of Cedecea pathogenesis, underscoring the importance of aggressive management of these bacterial infections in immunocompromised populations. The PubMed search revealed a total of 13 cases in which C. davisae was isolated from various clinical specimens, including blood (Dalamaga et al., 2008b; Peretz et al., 2013; Perkins et al., 1986; Abate et al., 2011; Akinosoglou et al., 2012; Kanakadandi et al., 2019), sputum (Bae et al., 1981; Ismaael et al., 2012), urine (Ammenouche et al., 2014), cutaneous and oral ulcers (Dalamaga et al., 2008b; Mawardi et al., 2010), and a scrotal abscess (Bae and Sureka, 1983). The identification of C. davisae from different host sites indicates an extended clinical spectrum of infections.
First reported case of pneumonia caused by Cedecea lapagei in America
2013, Brazilian Journal of Infectious DiseasesSurvey of Enterobacteriaceae contamination of table eggs collected from layer flocks in Australia
2013, International Journal of Food MicrobiologyCitation Excerpt :This microorganism was rarely reported in humans (Hess et al., 2008). There are very few reports of Cedecea isolation from eggshells and the clinical significance of Cedecea is not fully understood (Abate et al., 2011). In the present study, out of all Enterobacteriaceae genus reported, Escherichia was reported most frequently.
Bacteraemia due to Cedecea davisae in a patient with sigmoid colon cancer: A case report and brief review of the literature
2012, Diagnostic Microbiology and Infectious DiseaseCitation Excerpt :To the best of our knowledge, there are only 7 reported cases of Cedecea bacteraemia, among which 4 were C. davisae, 2 C. neteri, and 1 C. lapagei. Three cases (Abate et al., 2011; Aguilera et al., 1995; Perkins et al., 1986) developed Cedecea bacteraemia after long hospitalization (25–45 days), indicating the possibility that the infection may have been of nosocomial origin. Two more cases were described within a short period of time (15 days apart) in the same hospital (1 room apart from each other), suggesting a potential common source of the organism or cross infection, possibly of intranosocomial origin (Bae et al., 1981).
Predicting cancer prognosis and drug response from the tumor microbiome
2022, Nature Communications