Review articleInjectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review
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Graphical abstract
Keywords
Injectable gels
Drug delivery system
Neurological disorders
Brain cancer
Polymer design
Abbreviations
AD
Alzheimer's disease
aFGF
acidic fibroblast growth factor
AIBA
2,2′-azobis [2-methylpropionamide] dihydrochloride
BBB
blood brain barrier
BBTB
blood brain tumor barrier
BCSFB
blood cerebrospinal fluid barrier
BDNF
brain-derived neurotrophilc factor
bFGF
basic fibroblast growth factor
BMA
butylmethacrylate
BSA
bovine serum albumin
CED
convention enhanced delivery
CMC
carboxymethylcellulose
CNS
central nervous system
CSF
cerebrospinal fluid
DFO
deferoxamine mesylate
DOX
doxorubicin
DPSC
dental pulp stem cells
DSC
differential scanning calorimetry
dscECM
descellularized spinal cord extracellular matrix
ECM
extracellular matrix
EGF
epidermal growth factor
EMA
European Medicine Agency
EPO
erythropoietin
FGF-2
fibroblast growth factor-2
FUS
focused ultrasound
G'
storage modulus
G"
loss modulus
GBM
glioblastoma
GDNF
glial-derived neurotrophic factor
GF
growth factor
HA
hyaluronan
HP
heparin-poloxamer
ICV
intracerebroventricular
IP
intraperitoneal
IT-L
intrathecal-lumbar
LSCT
lower critical solution temperature
MC
methylcellulose
MFG-E8
milk fat globule-epidermal growth factor 8
MSC
mesenchymal stem cells
MSC
microsphere
NGF
nerve growth factor
NIPAAm
N-isopropylacrylamide
NP
nanoparticle
NSC
neural stem cells
NT-3
neurotrophin-3
PAA
poly(amidoamine)
Pcgel
PEG-g-chitosan
PCL
polycaprolactone
PD
Parkinson's disease
PEG
poly(ethylene glycol)
PEGMA
poly(ethylene glycol) methacrylate
PGRN
progranulin
PLA
poly(lactic acid)
PLGA
poly(lactic-co-glycolic acid)
pNIPAAm
poly(N-isopropylacrylamide)
PTX
paclitaxel
RNS
reactive nitrogen species
ROS
reactive oxygen species
SCI
spinal cord injury
TBI
traumatic brain injury
TGP
thermoreversible gelation polymer
TMZ
temozolomide
VEGF
vascular endothelial growth factor
ν
viscosity
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These authors share the senior authorship.
© 2020 The Author(s). Published by Elsevier B.V.