Journal of Biological Chemistry
Volume 298, Issue 5, May 2022, 101897
Research ArticleMetabolic changes accompanying the loss of fumarate hydratase and malate–quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum
Under a Creative Commons license
open access
Keywords
malaria
Plasmodium falciparum
mitochondrion
tricarboxylic acid cycle
aspartate shuttle
DiCre
metabolomics
oxaloacetate
Abbreviations
AAT
aspartate aminotransferase
ADSS
adenylosuccinate synthase
ARSL
argininosuccinate lyase
aTC
anhydrotetracycline
CMA
Complete Medium with Albumax
DHODH
dihydroorotate dehydrogenase
diCre
dimerizable Cre
FC
fold change
FH
fumarate hydratase
ΔFM
double knockout mutant of FH and MQO
gRNA
guide RNA
HA
homology arm
IDC
intraerythrocytic developmental cycle
iRBC
infected red blood cell
mETC
mitochondrial electron transport chain
MQO
malate–quinone oxidoreductase
PEP
phosphoenolpyruvate
PEPC
phosphoenolpyruvate carboxylase
RBC
red blood cell
RT
room temperature
SFG
superfolder GFP
S7P
sedoheptulose 7-phosphate
TCA
tricarboxylic acid
uRBC
uninfected red blood cell
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© 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.