Journal of Biological Chemistry
Volume 297, Issue 3, September 2021, 101088
Research ArticleThe deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation
Under a Creative Commons license
open access
Keywords
PTEN
deubiquitinase
USP10
K63-linked polyubiquitination
NSCLC
Abbreviations
CHX
cycloheximide
Dub
deubiquitinase
EdU
5-ethynyl-2′-deoxyuridine
HEK293T
human embryonic kidney 293T
IB
immunoblotting
IgG
immunoglobulin G
IP
immunoprecipitation
mTOR
mammalian target of rapamycin
MTT
3-(4,5-dimethylthylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide
NSCLC
non–small cell lung cancer
PI(3,4,5)P3
phosphatidylinositol-3,4,5-trisphosphate
PI3K
phosphatidylinositol-3-kinase
PTEN
phosphatase and tensin homolog deleted on chromosome 10
sgRNA
single-guide RNA
TRIM25
tripartite motif containing 25
USP10
ubiquitin-specific protease 10
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© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.