The Journal of Allergy and Clinical Immunology: In Practice
Original ArticleFEF25-75% Is a More Sensitive Measure Reflecting Airway Dysfunction in Patients with Asthma: A Comparison Study Using FEF25-75% and FEV1%
Section snippets
Patients
We screened data from adult patients aged between 18 and 65 years with a diagnosis of asthma who have performed lung function tests for baseline assessment or routine follow-up for clinical treatment at the Spirometry Department at the First Affiliated Hospital of Guangzhou Medical University from 2017 to 2019. Patients with asthma were confirmed by a history of variable respiratory symptoms, including wheezing, shortness of breath, chest tightness, and cough, as well as objective evidence of a
Patients
After screening data including a total of 9,677 results from the electronic database of the Department of Spirometry Laboratory of the First Affiliated Hospital of Guangzhou Medical University from 2017 to 2019, 1801 adult patients with confirmed asthma met our inclusive criteria. The spirometry results of these individuals underwent analysis (Figure 1). Among the cohort, 902 (50.08%), 333 (18.49%), 209 (11.60%), 124 (6.89%), 148 (8.22%), and 85 (4.72%) individuals had FEV1 ≥ 80%, 70%-79%,
Discussion
Our study is, to the best of our knowledge, the first study to compare the difference between FEF25-75% and FEV1% with respect to their associations with clinical characteristics in adult asthmatic patients with a broad range of lung function impairments. The main findings were as follows: (1) FEF25-75% was strongly correlated with FEV1%; (2) FEF25-75% and FEV1% showed similar clinical relevance, but FEF25-75% had a stronger correlated level with airway hyperresponsiveness and was more
Acknowledgments
We thank LetPub (www.letpub.com) for its linguistic assistance and scientific consultation during the preparation of this manuscript.
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2022, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Each value, which consisted of the best of 3 reproducible measurements, was expressed as a percentage of predicted computed using the equations of Quanjer and Stocks.21,22 Small-airway dysfunction was judged as FEF25%-75% values less than 65% of predicted.23 Lung hyperinflation was suggested by RV values greater than 120% of predicted and RV/TLC ratio greater than 30%.22
This work was supported by a Precision Medicine Research grant from the National Key Research and Development Plan of China (grant no. 2016YFC0905800), the Breeding Program of the Major Research Plan (9154204) of the National Natural Science Foundation of China, and the Key Project of the National Natural Science Foundation of China-Guangdong United Fund (U1801286) and special funding for science and technology development from Guangdong province (Frontier and key technology innovation direction—major science and technology special project) (2017B020226006).
Conflicts of interest: The authors declare that they have no relevant conflicts of interest.
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Co-first authors.