The Present and FutureState-of-the-Art ReviewGenome-Wide Significant Loci: How Important Are They?: Systems Genetics to Understand Heritability of Coronary Artery Disease and Other Common Complex Disorders
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Drs. Björkegren, Kovacic, and Schadt are supported by the American Heart Association (14SFRN20490315; 14SFRN20840000) and are members of the Consortium “CAD Genomics” (Drs. Björkegren and Schadt) and the Consortium “Cellular and Molecular Targets to Promote Therapeutic Cardiac Regeneration” (Dr. Kovacic), both of which are funded by the Leducq Foundation (Transatlantic Network of Excellence Awards). Dr. Björkegren is also supported by the Swedish Heart-Lung Foundation, the Swedish Research Council, the University of Tartu (SP1GVARENG), the Estonian Research Council, and by a grant from AstraZeneca Translational Science Centre-Karolinska Institutet (joint research program in translational science); and is the founder, a main shareholder, and chairman of the board of Clinical Gene Networks AB (CGN), which has invested interests in the STARNET and STAGE cohorts. Dr. Kovacic is also supported by the National Institutes of Health (K08HL111330) and by a research grant from AstraZeneca. Dr. Dudley is supported in part by funding from the National Institutes of Health (R01 DK098242 and U54 CA189201); and by the PhRMA Foundation. Dr. Schadt is a CGN board member and shareholder. Robert Roberts, MD, served as Guest Editor for this paper.