Preclinical ResearchActivation of Cardiac Adenylyl Cyclase Expression Increases Function of the Failing Ischemic Heart in Mice
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Abbreviations and Acronyms
ACVI
adenylyl cyclase VI
cAMP
cyclic adenosine monophosphate
CHF
congestive heart failure
+dP/dt
pressure development
EF
ejection fraction
ESP
end-systolic pressure
ESPVR
end-systolic pressure–volume relationship
FAC
fractional area change
LV
left ventricular
MI
myocardial infarction
MMP
matrix metalloproteinase
PKA
protein kinase A
PP1
protein phosphatases 1
PP2A
protein phosphatases 2A
RLU
relative light units
SR
sarcoplasmic reticulum
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This work was supported by National Institutes of Health grants 5P01HL066941, HL088426, and HL081741 (Dr. Hammond), Merit Review Awards from the Department of Veteran’s Affairs (Drs. Roth and Hammond), a Grant-in-Aid from the American Heart Association Western States Affiliate (Dr. Gao), and a fellowship from the Banyu Life Science Foundation International (Dr. Takahashi). Drs. Lai and Tang contributed equally to this work. Lynne Warner Stevenson, MD, served as Guest Editor for this article.
Copyright © 2008 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.