Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line

doi:10.1016/j.inoche.2019.107645

Inorganic Chemistry Communications

Volume 111, January 2020, 107645

https://doi.org/10.1016/j.inoche.2019.107645 Get rights and content

Highlights

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Eight new metal complexes were synthesized and characterized.
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All compounds (S3–S10) were screened against A549 cell line.
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S3–S10 had cytotoxic effect on lung cancerous cells.

Abstract

In this study, a new compound namely 1-((2-hydroxynaphthalen-1-yl)methyleneamino)-5-(4-methybenzoyl)-4-p-tolylpyrimidin-2(1H)-one (S2) was synthesized as a Schiff base using 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-one (S1) with 2-hydroxy-1-naphthaldehyde in 80% yield. Then, eight novel metal complexes (S3–S10) including Ni(II), Cu(II), Co(II), Ag(I), Pd(II), Pt(II), Cr(III), and Mn(II) metal ions were prepared from this new Schiff base (S2). The characterization of these complexes was done using ¹H NMR, ¹³C NMR, LC-MS, IR, magnetic susceptibility and conductivity measurements. The anticancer activities of compounds (S3–S10) were tested against human epithelial lung carcinoma cell line (A549) for 72 h. All complexes demonstrated antiproliferative activity in A549 cell line and low half-maximal inhibitory concentration (IC₅₀) values were calculated with GraphPad Prism program.

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Declaration of Competing Interest

The authors have no conflict of interest to declare.

Acknowledgments

This study was financially supported by Erciyes University Research Fund (FBA-2018-7643).

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Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line

Highlights

Abstract

Graphical abstract

Section snippets

Declaration of Competing Interest

Acknowledgments

Eur. J. Med. Chem.

Toxicol. In Vitro

Bioorg. Chem.

J. Mol. Struct.

Arabian J. Chem.

Eur. J. Med. Chem.

Bioorg. Chem.

Eur. J. Med. Chem.

J. Mol. Struct.

J. Microbiol. Methods

J. Mol. Struct.

Eur. J. Med. Chem.

Eur. J. Med. Chem.