Transcription Factor Theft—PU.1 Caught Red-Handed

doi:10.1016/j.immuni.2018.05.007

Immunity

Volume 48, Issue 6, 19 June 2018, Pages 1063-1065

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The mechanistic understanding of gene-expression regulation is still evolving. In this issue of Immunity, Hosokawa et al. (2018) reveal that PU.1 represses transcription indirectly during early T cell development by “stealing” other regulators such as Runx1 and Satb1 from their DNA binding sites.

Immunity

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Transcription Factor Theft—PU.1 Caught Red-Handed