Elsevier

Gene

Volume 808, 15 January 2022, 145997
Gene

Dynamical network biomarkers: Theory and applications

https://doi.org/10.1016/j.gene.2021.145997Get rights and content
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Abstract

This paper reviews theory of DNB (Dynamical Network Biomarkers) and its applications including both modern medicine and traditional medicine. We show that omics data such as gene/protein expression profiles can be effectively used to detect pre-disease states before critical transitions from healthy states to disease states by using the DNB theory. The DNB theory with big biological data is expected to lead to ultra-early precision and preventive medicine.

Abbreviations

DNB
Dynamical Network Biomarker
DNM
Dynamical Network Marker
SSN
Single-Sample Network

Keywords

Dynamical network biomarker
Healthy state
Pre-disease state
Disease state
Bifurcation
Tipping point
Early warning signals
Ultra-early medicine

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