Elsevier

Fitoterapia

Volume 78, Issue 3, April 2007, Pages 263-264
Fitoterapia

Short report
Antioxidant activity of Agaricus blazei

https://doi.org/10.1016/j.fitote.2007.01.002Get rights and content

Abstract

The ethanolic extract of Agaricus blazei and ethyl acetate and hydroalcoholic fractions were evaluated for their antioxidant activity.

Section snippets

Plant

A. blazei fruiting bodies, collected on “Estancia Valemar” (Sao Jose do Rio Preto — SP) were identified by Dr. Arailde Fontes Urben (EMBRAPA researcher).

Uses in traditional medicine

The infusion of the fruiting body has traditionally been used in Brazil for prevention of cancer [1], [2], [3], [4], and diabetes, hyperlipidemia, arteriosclerosis and chronic hepatitis activities [5].

Previously isolated classes of constituents

Ergosterol [5], polysaccharides [2], [6], [7] and phenolic compounds [8].

Tested material

Ethanol extract (yield: 4.43%) of the dried (40 °C) material and ethylacetate fraction (yield: 2.25%) and hydroxyalcoholic soluble fraction (0.54%).

Studied activity

Bleaching of the DPPH [9], [10] and ABTS•+ radicals [11].

Results

Reported in Table 1.

Conclusions

The ethanolic extract and the ethyl acetate and hydroalcoholic fractions from A. blazei have a powerful antioxidant activity useful for the treatment of various diseases mediated by radicals species.

Acknowledgements

This work was supported by grants provided by FAPESP. Adriano Silva Fernandes is grateful to CAPES for scholarship.

References (11)

  • H. Itoh et al.

    Jpn J Pharmacol

    (1994)
  • H. Kawagishi et al.

    Carbohydr Polym

    (1990)
  • T. Takaku et al.

    J Nutr

    (2001)
  • S. Dall'Acqua et al.

    Fitoterapia

    (2004)
  • S.S. Chun et al.

    Proc Biochem

    (2005)
There are more references available in the full text version of this article.

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