Trajectory of cognitive impairments over 1 year after COVID‐19 hospitalisation: Pattern, severity, and functional implications

The ongoing Coronavirus Disease (COVID-19) pandemic has so far affected more than 500 million people. Lingering fatigue and cognitive difficulties are key concerns because they impede productivity and quality of life. However, the prevalence and duration of neurocognitive sequelae and association with functional outcomes after COVID-19 are unclear. This longitudinal study explored the frequency, severity and pattern of cognitive impairment and functional implications 1 year after hospitalisation with COVID-19 and its trajectory from 3 months after hospitalisation. Patients who had been hospitalised with COVID-19 from our previously published 3-months study at the Copenhagen University Hospital were re-invited for a 1-year follow-up assessment of cognitive function, functioning and depression symptoms. Twenty-five of the 29 previously assessed patients (86%) were re-assessed after 1 year (11±2 months). Clinically significant cognitive impairments were identified in 48-56 % of patients depending on the cut-off, with verbal learning and executive function being most severely affected. This was comparable to the frequency of impairments observed after 3 months. Objectively measured cognitive impairments scaled with subjective cognitive difficulties, reduced work capacity and poorer quality of life. Further, cognitive impairments after 3 months were associated with the severity of subsequent depressive symptoms after 1 year. In conclusion, the stable cognitive impairments in approximately half of patients hospitalized with COVID-19 and negative implications for work functioning, quality of life and mood symptoms underline the importance of screening for and addressing cognitive sequelae after severe COVID-19.


Introduction
The ongoing pandemic caused by the SARS-CoV-2 virus  has so far affected more than 420 million people worldwide. A key concern is the frequent lingering physical, cognitive, neurological or psychiatric symptoms that persist for 12 or more weeks after the recovery from acute illness and are collectively referred to as 'long-COVID', or 'post-COVID syndrome' (NICE., 2021). While studies have shown that even asymptomatic or mild infection may lead to persistent symptoms (Bliddal et al., 2021;de Graaf et al., 2021), the risk appears to be greater amongst those with severe COVID-19 illness (Nakamura et al., 2021;Schou et al., 2021;Taquet et al., 2021a), older age and greater comorbidity (Ceban et al., 2022). Accordingly, studies indicate that the frequency of long-COVID symptoms is 20-40 % in general (Bliddal et al., 2021;Llach and Vieta, 2021;Logue et al., 2021), but up to 85% for patients who have been hospitalised with COVID-19 (Vejen et al., 2022). Given this high prevalence of lingering symptoms, inter-disciplinary long-COVID clinics have been established to address the needs of these patients.
Long-term cognitive sequalae of COVID-19, also coined cognitive COVID, involve fatigue, 'brain fog', memory and concentration difficulties. Meta-analytic evidence indicates that cognitive COVID occurs in 20-30% of people with COVID-19 in general (Ceban et al., 2022) and in around 30% of hospitalized COVID-19 patients (Nakamura et al., 2021;Schou et al., 2021), with executive function, memory, and attention being most affected (Nakamura et al., 2021;Schou et al., 2021). Further, a large-scale internet-based study with > 80,000 patients with or without COVID-19, suggested executive dysfunction of substantial effect size, 6-months after infection in both hospitalized and non-hospitalized patients (Hampshire et al., 2021). Notably, estimates of cognitive impairments varied across the included original studies, likely due to differences in the sensitivity of the implemented cognitive test batteries (including MoCA, MMSE, SCIP, WAIS-IV) (Schou et al., 2021). We found, using a sensitive cognitive screener devoid of ceiling effects in populations with work-related stress  or psychiatric conditions (Ott et al., 2021), that 59-65 % of hospitalized patients displayed clinically significant verbal learning and memory, executive function and working memory impairments 3months after hospital discharge . The biological mechanisms underlying these cognitive symptoms are likely multifactorial; Acute and ongoing systemic inflammation due to autoimmunity complications, direct viral invasion of the central nervous system due to leakiness of the blood-brain-barrier (Pajo et al., 2021;Proal and VanElzakker, 2021) and cerebral microhaemorrhages, as identified by white matter hyperintensities, may all play a key role (Baldini et al., 2021;Mazza et al., 2021a;Moonis et al., 2020;Scardua Silva et al., 2021). From a biopsychosocial perspective, additional contributing factors to cognitive COVID may be the social aspect of having a serious illness, stigma, and isolation and inactivity related to the pandemic (Grover et al., 2021;Sykes et al., 2021).
The duration of cognitive COVID and long-term impact on functioning and quality of life are unclear.
One study of hospitalized patients (n = 312) indicated little to no cognitive improvement within the first 6 months, with observations of cognitive impairments in 79% and 75% of patients after 3-months and 6-months, respectively (Poletti et al., 2021). Another longitudinal study found that overall, 47 % of patients had cognitive impairments. Specifically, 21% had memory impairments, 12% had executive dysfunction 1 year after hospitalisation (Méndez et al., 2021). A third study identified concentration difficulties in 31 % of patients 1 year after hospital discharge (Becker et al., 2021). Notably, 45 % of patients in the latter study, who had no prior history of psychiatric illness, reported psychiatric morbidity and poorer quality of life following COVID-19 (Méndez et al., 2021). This is comparable to a large-scale study (n= 236 379), which demonstrated that within 6months after COVID-19, 38 % of hospitalised patients received a neuropsychiatric diagnosis (14 % with first onset), most commonly depression or anxiety (Taquet et al., 2021b). This co-occurrence of cognitive and psychiatric sequelae of COVID-19 is noteworthy given pre-existing evidence for close links between cognitive and depressive symptoms (Nys et al., 2006;Weiland-Fiedler et al., 2004;Weisenbach et al., 2012). This raises the possibility that these symptoms are interlinked. Indeed, cognitive impairment is a key contributor to functional impairment and mood symptoms across several neuropsychiatric illnesses (Cambridge et al., 2018;Mitchell et al., 2014;Woo et al., 2016), whereas depressive symptoms may also exacerbate cognitive impairments (McDermott and Ebmeier, 2009).
The present longitudinal study of patients hospitalized with COVID-19 aimed to explore (I) the frequency, pattern, and severity of cognitive impairments 1 year after hospitalisation with COVID-19, (II) the trajectory of cognitive impairments from 3 months to 1 year after hospitalisation, (III) the association between cognitive impairments, functioning and quality of life, and (IV) whether cognitive impairments 3 months after hospitalisation are associated with subsequent depression symptoms after 1 year.

Participants and recruitment
Participants were recruited to take part in a prospective follow-up study 'IMPACT-COVID' examining all adult patients (≥ 18 years) admitted with COVID-19 to Bispebjerg Hospital in Denmark from March 2020 until the end of the first wave of COVID-19 cases in June 2020 (Johnsen et al., 2021). COVID-19 diagnosis was confirmed upon hospitalisation based on a positive polymerase chain reaction (PCR) test for SARS-CoV-2 from the upper respiratory tract or a positive IgG titer for COVID-19. Participants were recruited as part of their 3months post discharge assessment of physical and cognitive functions (see Johnsen et al 2021;Miskowiak et al 2021). Participants were excluded from the study if they presented insufficient Danish language abilities or preexisting neurological comorbidities. Prior to data collection, regional ethics committee in the Capital Region of Denmark approval was obtained for all study procedures (protocol no. H-20035553). All participants provided informed written consent prior to study enrolment. For the present follow-up study, patients who underwent cognitive screening at their 3-months assessment, were re-invited by telephone call for a re-assessment approximately 1 year after hospital discharge.

Procedure
Patients attended the long-COVID clinic at the Bispebjerg Hospital or the Psychiatric Centre Copenhagen, Rigshospitalet, for a 1-year follow-up assessment of objective (performance-based) and subjective (selfreported) cognitive functions, mood symptoms, quality of life and work function (duration of approximately 1 hour).
Work functioning was assessed for patients who were currently employed with the Work Productivity and Activity Impairment Questionnaire (WPAI; Reilly et al, 1993), a 6-item self-report questionnaire assessing absenteeism, presenteeism, and activity impairments due to health problems in the past 7 days (e.g., "how many hours did you miss from work because of your health problems") (WPAI; Reilly et al, 1993). Quality of Life was assessed with the EQ-5D-5L quality of life questionnaire which is comprised of 5 dimensions: self-care, usual activities, pain/discomfort, mobility, and anxiety/depression. (EQ5D; Lloyd and Pickard, 2019).

Statistical analysis
All statistical tests were conducted using IBM SPSS statistics 25 for windows (IBM Corporation, Armonk, New York) with a significance level of  = 0.05 (two-tailed). Prior to statistical analyses relevant assumptions were tested. Regarding normality, appropriate analyses (parametric and non-parametric) tests were used accordingly for normally and non-normally distributed data.

Question (I):
What is the frequency, pattern, and severity of cognitive impairments 1 year after hospital discharge?
This research question was examined with two complementary approaches: by comparing patients' cognitive performance at their 1-year assessment (A) to their individual expected performance calculated with the regression based formulas based on their age, sex, years of education and the normative (expected) cognitive change with repeated testing (i.e., expected performance considering learning effects with repeated testing, as they had been tested previously, 3 months after hospital discharge) (Supplementary Table 1) and (B) to the cognitive performance of an age-, gender-and education-matched sample of 55 health controls (HC) from a preestablished normative data set following repeated testing (Ott et al., 2021).
In approach (A), regression-based formulas were applied for prediction of each patients expected SCIP test scores based on their age, sex, and years of education following repeated testing (Ott et al., 2021). The regression-based formula allows calculation of demographically corrected normative scores, applicable at an individual level (Duff, 2012). This enables precise estimation for each patient of whether their cognition scores deviate or align with the expected scores of a person with matched demographic characteristics. Reliable change indexes (RCI) provide standardized scores for the deviation of the observed scores from the predicted scores, calculated as (observed scorepredicted score)/SEE, with SEE reflecting the standard error of the estimate for the regression equation (Attix et al., 2009). These regression-based models have previously been used to determine demographically adjusted norms and normative cognitive change over 1 year (Ott et al., 2021).
The frequency of clinically relevant 'global cognitive impairment' was based on a cut-off score defined as performance ≥1 standard deviations (SD) under the expected SCIP-D total score, whereas 'selective cognitive impairment' was defined as performance ≥1SD under the expected scores on ≥2 individual tests in the SCIP-D or TMT-B (Ott et al., 2021) (approach A). The same cut-offs for global and selective impairments were applied when estimating the frequency of clinically relevant cognitive impairments relative to the matched HC sample (approach B). These cut-offs for clinically relevant cognitive impairments were determined based on previous recommendations (Ott et al., 2021;Miskowiak et al., 2018).
Accordingly, the pattern of cognitive impairments was explored through comparisons between: (A) patients' actual scores on SCIP-D and TMT-B at the 1-year assessment and their expected scores, using independent samples t-tests. For the TMT-B, normative change scores are not available. We therefore compared patients TMT-B scores with the normative cross-sectional TMT-B norms, based on our observation that TMT-B scores show no signs of learning effects with repeated testing in a large sample of HC (n= 141) from our ongoing cohort study (Kessing et al., 2017) over a period of 16-months (change, mean ± SD: 2.9±13.4).
Regarding (B), comparisons were made between patients' SCIP-D scores after 1 year and those of the demographically matched HC group (TMT-B data not available for the HC group).
For normally and non-normally distributed data, Independent Samples t-tests and Mann-Whitney U tests were conducted, respectively. Severity of cognitive impairments (relative to expected performance [approach (A)] and cognitive performance in HC [approach (B)], respectively) was determined based on effect sizes for significant differences. For normally distributed data, Cohen's d effect sizes were estimated. For nonnormally distributed data, effect sizes r were estimated (r = Z-score / √N) (Fritz et al., 2012). Due to unequal sample sizes between patient-and the HC group, severity of cognitive impairments relative to cognitive performance in the HC group, was estimated with Hedges' g.
Question (II): Does cognition improve from 3 months to 1 year after hospitalisation?
This question was explored using the expected change norms based on participants' age and baseline scores (Ott et al., 2021). To explore whether proportions of patients with global or selective cognitive impairment at the 1year assessment were significantly different from 3 months post-discharge, we used non-parametric McNemar's tests for paired nominal data.
In addition, we analysed differences between patients' actual change and expected change SCIP-D scores between the two assessments using paired sample t-tests, in line with approach (A). Further, we compared patients' SCIP-D change scores between 3 months and 1 year with change scores in the HC group using independent sample t-tests (consistent with approach [B]). Since TMT-B data was not available for HC but is stable over time (Kessing et al., 2017), we analysed patients' change in TMT-B through paired sample ttests Question (III): Are cognitive impairments associated with functioning and quality of life?
This was investigated with Pearson's correlations or Spearman's rho for normally and non-normally distributed data, respectively. The deviation from expected scores using the RCI for patients' SCIP-D total scores was applied as a measure in the analyses of associations between objective cognitive function and subjective cognitive complaints, quality of life, mood symptoms and work function.
Question (IV): Are cognitive impairments 3 months after hospitalisation related to mood symptoms after 1 year?
This question was analysed with Pearson correlation analysis. SCIP Total score at 3-months was used as a measure investigating the association with depressive symptoms at 1-year as measured by Hamilton Depression Rating Scale (HDRS-17).

Participants
Following hospitalisation for COVID-19 at Bispebjerg Hospital, 70 % of patients (n= 83) were offered followup at two-time points; 3-months and 11-months. Of those offered participation in the study, 86 % accepted (n= 71) (See Miskowiak et al., 2021). Figure 1 illustrates the recruitment process (See Appendix A). For the 3 months follow-up, 29 patients took part (n= 29). The results of the 3 months cognition assessments have previously been published . For the 1-year (mean±SD: 11±2 months) follow-up, we reassessed 25 (86%) of these patients. Of the 4 patients lost to follow-up, 1 had moved abroad while the other 3 were unreachable by telephone. Importantly, these 4 patients did not differ significantly from the remaining patients on the demographic variables age and gender (p-levels > .09). Clinical and demographical characteristics of the resulting sample (n= 25) are displayed in Table 1.

Question (I): What is the frequency, pattern, and severity of cognitive impairments 1 year after hospital discharge?
In total, 14 (56%) patients fulfilled the criterion for clinically relevant cognitive impairments compared with their expected performance based on their individual age, education level and gender; 12 (48 %) patients fulfilled the criterion for global impairment, and 2 (8%) patients as selectively impaired, while 11 (44%) were cognitively normal. In comparison with the HC sample, 12 (48%) patients were identified as cognitively impaired; 10 (40%) with global impairments and 2 (8%) with selective impairment, while 13 (52%) were cognitively normal. Cognition data from patients, expected scores and HC is displayed in  Non-significant trends toward group differences were found for psychomotor speed and verbal fluency (PST: t= 1.84, df= 32.24, p= 0.076, Hedges' g= 0.53; VFT: t= 1.87, df = 78, p = 0.065, Hedges' g= 0.45). The pattern of cognitive deficits across groups is displayed in Figure 3.

Question (II): Does cognition improve from 3 months to 1 year after hospitalisation?
There was no significant difference in the proportion of patients with global or selective cognitive impairment between the 3-months assessment (32% and 24 %, respectively) and the 11-months assessment (48% and 8%, respectively) (p-values ≥.22 and ≥.13. respectively). Cognitive change in individual patients from 3-months to 11-months is illustrated in Figure 4.
There were also no significant differences between patients' test scores at 3 months and 1 year on the SCIP-D or TMT-B (p-vales ≥ 0.19). However, when adjusting the analyses for the normative change due to learning effects with repeated testing, patients showed a lack of the expected increase over time in SCIP-D total scores Global cognitive impairment also correlated strongly with impairments in several aspects of work function measured with the WPAI, including work productivity loss' (i.e., overall work impairment; Spearman's Rho; r= -0.75, p= 0.01), 'presenteeism' (i.e., impairment at work; Spearman's Rho'; r= -0.70, p= 0.01), and 'activity impairment' (Spearman's Rho; r= -0.69, p <.01). In contrast, no relation was found between global cognitive impairment and the WPAI 'absenteeism' (i.e., work time missed) (p≥.46).

Question (IV): Are cognitive impairments 3 months after hospitalisation related to mood symptoms after 1 year?
A moderate correlation was found between cognitive impairments 3 months after hospital discharge and the severity of depressive symptoms after 11 months (Pearson's correlation; r= -0.49, p= 0.04).

Discussion
In this longitudinal study of patients hospitalised with COVID-19, we examined the frequency and pattern of cognitive impairments and associations with quality of life and work functioning 1 year after hospital discharge (mean±SD; 11±2 months) and the cognitive trajectory from patients' prior 3-months assessments (Miskowiak et al., 2021). The percentages of patients with clinically relevant cognitive impairments after 1 year were 48 % and 56 % when compared to a matched healthy control group and demographically adjusted norms, respectively. This did not differ significantly from the frequency of impairments observed 3 months after hospitalisation.
Regarding the pattern of deficits, verbal learning and executive function were most affected, with moderate to large effect sizes for deficits in these domains. These objective cognitive impairments correlated strongly with overall work impairment, presenteeism, and activity impairment. In addition, objective cognitive impairments correlated moderately with subjective cognitive difficulties and with poorer quality of life, including poor health, pain, anxiety and depression. Finally, cognitive impairments 3 months after hospitalisation correlated moderately with depressive symptoms 1 year after hospitalisation.
The observed trajectory of cognitive functions from 3 months to 1 year after hospitalisation with COVID-19 indicates that patients with impaired cognition 3 months after hospitalisation do not improve after 1 year, while patients with no impairments after 3 months remain cognitively normal. This is consistent with meta-analytic evidence suggesting patients' cognitive impairments after COVID-19 persist over time (Ceban et al., 2022). Our findings corroborate with 3 longitudinal studies that identified cognitive impairments both 6 (Poletti et al., 2021) and 12 months (Méndez et al., 2021;Ferrucci et al., 2022) after COVID-19 hospitalisation, with most pronounced impairments within verbal learning, memory and executive function (Méndez et al., 2021). While Ferrucci and colleagues observed improvement in verbal memory, attention, and processing speed, cognitive functions were still affected after 1 year, with processing speed, visuospatial and verbal memory being most affected (Ferrucci et al., 2022). No study has yet investigated whether cognitive COVID persists beyond 1 year. However, longer-term follow-up assessment of patients with other respiratory illnesses, including SARS-CoV-1 and MERS, indicates that neurocognitive and functional impairments may last up to 5 years after hospitalisation with these diseases, particularly in severely ill patients with acute respiratory distress syndrome (ARDS) (O'Sullivan, 2021;Sasannejad et al., 2019). Nevertheless, studies with longer follow-up times are needed to determine the long-term trajectory of cognitive deficits after COVID-19.
The moderate to strong associations between cognitive impairments and daily functioning, quality of life and low mood 1 year after hospitalisation with COVID-19 is noteworthy. This finding is in keeping with the observation by Mendez and colleagues in a larger sample of patients (n=171) that cognitive impairments, subjective cognitive complaints, psychiatric morbidity, and poorer quality of life are prevalent 1 year after hospitalisation with COVID-19 (Méndez et al., 2021). The lack of cognitive improvements from 3 months to 1 year is also consistent with the observations that patients often do not return to previous levels of work capacity even 1 year after COVID-19 hospitalisation (Davis et al., 2021;Frontera et al., 2021). Importantly, we showed here for the first time that cognitive impairments are strongly associated with reduced work capacity, and moderately associated with self-reported cognitive difficulties in daily life, poorer quality of life, and elevated mood symptoms 1 year after hospital discharge. In particular, the moderate correlation between objectively measured and subjective self-reported cognitive impairment suggests that patients' insight into their cognitive status was adequate. This contrasts with the generally poor correlation between subjective and objective cognition in patients with mood disorders (e.g., Petersen et al., 2019). Cognitive screening with easy-toadminister self-report measures may thus be adequate for patients in long-COVID clinics.
Interestingly, a longitudinal study of 1276 hospitalised patients in China revealed that while most patients had returned to work within 12 months after hospitalisation with COVID-19 (88%), a substantial subset (26 %) was battling with unchanged levels of mood symptoms from 6 to 12 months after their hospital discharge (L. Huang et al., 2021). It is likely that patients' return to work despite lingering symptoms will aid their recovery and regaining their cognitive abilities and daily functioning after COVID-19. Indeed, environmental stimulation seems crucial for enhancing and preserving cognitive function (Shaffer, 2016), possibly through a positive impact on patients' neuroplasticity. However, work demands should not exceed people's cognitive capacity, because this would likely result in stress and poor mental health. In this regard, cognitive screening after COVID-19 hospitalisation and implementation of appropriate support for patients with identified cognitive impairments may be clinically useful.
Depressive symptoms were found in a previous study to be the main predictor of impaired cognitive performance 6 months after hospitalisation with COVID-19 (Poletti et al., 2021). Our finding that cognitive impairments 3 months after hospitalisation were moderately associated with subsequent depressive symptomatology after 1 year provides preliminary evidence that the opposite may also be the case. While the sample size was too small for multiple regression analyses with covariation for other potential contributing factors, this association provides preliminary evidence for a potential role of cognitive COVID in the development of depressive symptoms. Cognitive impairments and mood symptoms are thus likely to have a bidirectional relation; In a mutually reinforcing cycle, cognitive impairments may exacerbate depression and anxiety symptoms due to difficulties overcoming cognitive challenges in daily life and work functioning and, thereby, result in poorer quality of life, stress, and mood symptoms. On the other hand, mood and anxiety symptoms may also exacerbate cognitive impairment and functional disability. This highlights a need to screen for and target both cognitive impairment and mood symptoms after severe COVID-19 illness. Regarding cognitive screening, the finding that objectively measured cognitive impairment scaled with subjectively selfreported cognitive difficulties indicates that patients may have accurate insight into their cognitive status. This supports the use of the CFQ or similar easy-to-administer self-report measures to screen for cognitive difficulties after COVID-19 illness.
While the functional implication of cognitive impairments after COVID-19 are evident, the neurobiological origins of these long-term impairments remain unclear and are likely multifactorial (Baldini et al., 2021;Mazza et al., 2021;Moonis et al., 2020;Scardua Silva et al., 2021). In our 3-months assessment study of these patients, we had observed that the degree of cognitive impairment was related to higher d-dimer levels during acute illness and residual pulmonary dysfunction. This suggests that reduced oxygen delivery to the brain and possible thrombosis or coagulation may play a role in patients' cognitive impairments . In particular, the hippocampus -an essential brain structure for memory function-is highly susceptible to hypoxia-related injury, suggesting that cerebral oxygen starvation during acute illness may contribute to these patients' long-term verbal learning and memory difficulties.
The careful longitudinal evaluations over 1 year of cognition, functioning and quality of life and the well-defined sample of patients hospitalized with COVID-19 were strengths of the study . A key limitation, however, was the small sample size (n= 25) and consequent low statistical power, which limited our ability to conduct extensive and thorough statistical analyses of the associations between variables. Nevertheless, we were able to observe robust group differences in cognitive functions with moderate to large effect sizes, similar to a prior larger study (Méndez et al., 2021) as well as moderate to strong associations between cognitive impairments and work difficulties, mood symptoms and quality of life. It is possible that they experienced no cognitive-COVID, indicating that our findings may only be generalised to patients with lingering symptoms. However, the reasons for declining were often exhaustion and lack of energy for cognitive testing, which would speak against a sampling bias. Further, the lack of control group of patients with a different respiratory illness prevented insight into whether the observed cognitive impairments were specific to COVID-19 illness. Finally, SCIP-D is a brief cognition screener and may not replace comprehensive neuropsychological evaluation. Nevertheless, the SCIP-D is short, sensitive and feasible, rendering complete longitudinal datasets for all included participants.

Conclusion
In conclusion, our prospective follow-up study revealed that 48-56 % of patients suffer from clinically relevant cognitive impairments 1 year after hospitalisation with COVID-19, which were of a moderate to large effect size for the global cognition measure, verbal learning and executive function. Longitudinal analyses showed stability of these impairments from 3 months to 1 year after hospitalisation. Further, the cognitive impairments after 1 year were moderately to strongly associated with poorer quality of life, more mood symptoms and greater work impairments. The observed association between cognitive impairments after 3 months and severity of depressive symptoms 1 year after hospitalisation provides preliminary evidence for a possible role of cognitive status in mental health outcomes after hospitalisation with COVID-19. Based on these findings, we suggest that there is a need to assess and address cognitive difficulties, mood symptoms and functional impairments after severe COVID-19 illness.

Role of Funding Source
Department of Pulmonology Medicine and Respiratory Research Unit, Bispebjerg University Hospital, provided financial support for the study. The funder had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. and Pharmaxis in the past three years; SJ, DP and SMS report no conflicts of interest outside of the present work. Data is presented as mean (SD) or number (percentage) for demographics, clinical characteristics, and quality of life data. Work Productivity and Activity Impairment data is reported as median [minimum, maximum].
Missing data for n= 7 a, b, h, j, l , Missing data for n= 9 c, d, e, f, g , Missing data for n= 2 i ; Missing data for n= 1 k   following repeated testing andfor selective impairments -performance ≥1 SD below HC ≥2 individual tests.
Dark red = global cognitive impairment; light red= selective cognitive impairment; green= cognitively normal.