Short communicationAddressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder
Introduction
Urine drug testing is a standard monitoring procedure for patients treated for opioid use disorder (OUD). Clinically, it offers information regarding use of illicit substances, relapse, and adherence to treatment medications such as buprenorphine/naloxone (SAMHSA, 2012; Kirsh et al., 2015). Quantitative urine testing strategies, such as liquid chromatography-tandem mass spectrometry (LC–MS/MS), are highly sensitive and specific for identifying concentrations of selected substances in the urine (ASAM, 2013). The interpretation of those levels can be clinically challenging, however, and should be done with an understanding of the limitations of the test and the metabolism of the drug of interest (SAMHSA, 2012; Sethi and Petrakis, 2014). For example, a low norbuprenorphine (NB) level may represent a normal finding, medication nonadherence, medication diversion, concomitant intake of a cytochrome P450 inhibitor, or intentional urine dilution (adulteration) to mask identification of other substances. While urine testing can provide a clinically useful barometer of the effectiveness of the current treatment plan, patient context is critical to the accurate interpretation of these urine tests and to the subsequent treatment plan revision.
Previously, we have presented data demonstrating urine buprenorphine (B) and NB levels for patients actively treated with buprenorphine for OUD in an academic addiction medicine clinic (Donroe et al., 2017). We identified urine B and NB concentrations suggestive of urine adulteration (Donroe et al., 2017).
Under-reporting illicit drug use is common among both teens and adults (Delaney-Black et al., 2010; Harrison et al., 1993). One study of 2349 college students at a single large university found that 4.0% had ever deliberately deceived a physician to conceal illicit drug use, to conceal diversion of prescribed medications, or both (Stogner et al., 2014). Another retrospective chart review study of 168 patients enrolled in a buprenorphine treatment program found that 8 patients (4.8%) had diluted and adulterated their urine sample with buprenorphine film submersion at least once (Suzuki et al., 2017). Self-disclosure of recent illicit drug use by patients is predicated on many factors, including fear of a negative reaction from the provider, fear of real practical consequences (e.g. being discharged from the practice), perceived likelihood of “getting away with” urine adulteration, and the strength of the therapeutic relationship with the provider. Additionally, patients already engaged in treatment may be less likely to report ongoing cocaine or heroin use (51% and 67%, respectively) than patients at the start of their treatment (89% and 96%, respectively) (Hindin et al., 1994). These factors, and the specific methods used when asking patients to disclose recent substance use, strongly influence a patient’s decision to self-disclose (Bowling, 2005).
We present three cases in which we recognized discordant urine B and NB levels, used the information to initiate a discussion with each patient, and adjusted the treatment plan to better meet the patients’ needs. We describe an approach to addressing intentional adulteration of urine samples, in a way that we believe still adheres to the principles of harm-reduction (Marlatt et al., 2012), the centrality of the patient-provider relationship, and the acknowledgment that ongoing illicit drug use and subsequent dishonesty about disclosure is common among persons with substance use disorders.
Section snippets
Case patient A
Patient A is a 52-year-old man with OUD and prior opioid overdose. After induction with buprenorphine, he was stabilized at a dose of 12 mg twice daily. His urine testing is shown in Table 1. A long history of discordant B and NB levels are noted and reflects our own learning curve with the interpretation of urine B and NB levels. After nearly 10 months of treatment in our clinic, a treatment team member raised the subject of discordant urine drug testing results with the patient, using
Discussion
We present three cases in which our interpretation of urine B and NB concentrations led to concern for urine adulteration. In each case, quantitative B and NB urine testing provoked conversations with patients about their treatment course and current treatment needs. All three patients endorsed submerging a buprenorphine film and diluting their urine.
The recognition of urine adulteration was an important indication that adjustments to the current treatment plan were needed, to the benefit of
Role of funding
No conflicts declared for the authors.
Contributors
All authors contributed equally to the writing and editing of this manuscript. All authors have read and approved the final manuscript.
Conflict of interest
No conflict declared.
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