Eye hemodynamic data and biochemical parameters of the lacrimal fluid of patients with non-proliferative diabetic retinopathy

This paper presents a data from examinations of patients treated in clinic of Tashkent medical academy, Uzbekistan. 165 Patients (305 eyes) with NPDR were randomly allocated to receive standard treatment as the control group, in addition to the standard treatment daily tablets of EGb 761 (Tanakan, Beaufour Ipsen Industrie, Paris, France) 120 mg as the 1st main group, or daily endonasal electrophoresis of Tanakan 40 mg as 2nd main group, within 10 days. All of the patients underwent baseline ophthalmologic examinations, definition of biochemical parameters of the lacrimal fluid and Doppler ultrasound imaging of the eye. Moreover, correlation between tear fluid and hemodynamics was calculated. This data is essential for researchers to develop diagnostic criteria for diabetic retinopathy stages. Data are also beneficial to practitioners in determining the diabetic retinopathy severity and choosing appropriate treatment.


a b s t r a c t
This paper presents a data from examinations of patients treated in clinic of Tashkent medical academy, Uzbekistan. 165 Patients (305 eyes) with NPDR were randomly allocated to receive standard treatment as the control group, in addition to the standard treatment daily tablets of EGb 761 (Tanakan, Beaufour Ipsen Industrie, Paris, France) 120 mg as the 1st main group, or daily endonasal electrophoresis of Tanakan 40 mg as 2nd main group, within 10 days. All of the patients underwent baseline ophthalmologic examinations, definition of biochemical parameters of the lacrimal fluid and Doppler ultrasound imaging of the eye. Moreover, correlation between tear fluid and hemodynamics was calculated. This data is essential for researchers to develop diagnostic criteria for diabetic retinopathy stages. Data are also beneficial to practitioners in determining the diabetic retinopathy severity and choosing appropriate treatment.
© 2020 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) Table   Subject Ophthalmology Specific subject area Diabetic retinopathy, human retina, Biochemical parameters of the lacrimal fluid, antioxidant system in the tear, Doppler ultrasound imaging of the eye, hemodynamic parameters, correlation coefficients Type of data

Value of the Data
• These data show changes in the biochemical composition of the tears of patients with nonproliferative diabetic retinopathy. • These data show, that blood flow velocity changes with increasing severity of diabetic retinopathy. • These data can help ophthalmologists to make the correct diagnosis and stage of the disease.
• Correlation coefficients between diabetic retinopathy severity, the level of antioxidant protection system in the tear, and blood flow velocity valuable for the development of disease prognosis. Table 1 shows, that mean diabetic retinopathy severity (DRS) reduction in the 2nd main group was statistically significant compared with the baseline value ( p < 0.01) after treatment and remained at low values for 6 months [1] . On the contrary, in the control group, the decrease in DR severity after treatment was not statistically significant ( p > 0.05), and an increase in the severity of DR was observed at month 6.

Data Description
The antioxidant system in the tear of eye with DR is changed [ 2 , 3 ]. Our studies have shown a gradual decrease in NO levels as DRS increases. Table 2 show statistically significant ( р < 0.05) NO reduction and MDA increases from healthy group. Table 3 shows progressive decrease in blood flow in the second Ib and third Ic stage of NPDR in the central retinal artery (CRA) at baseline [ 4 , 5 ]. Also, a progressive decrease in blood flow by stages was detected in the short posterior ciliary artery (SPCA). Peak systolic velocity (PSV) reduction in Ib and Ic stage was statistically significant ( Р < 0.05) from healphy.
In the correlation analysis ( Table 4 ), a strong positive correlation was found ( r = 0.71) between PSV in the CRA and the level of NO in the eyes with the NPDR Ia stage. Moderate positive correlation was found between the PSV of the CRA and the level of NO in the eyes of NDR Ib and NPDR Ic, as well as between EDV in the CRA and the level of NO in the eyes of NPDR Ia ( r = 0.67). In addition, moderate positive correlations were found between RI CRA and catalase activity in NDR Ia (r = 0.45), SOD activity in NDR Ib ( r = 0.46), between PSV in CRV and the level NPDR = non-proliferative diabetic retinopathy. * р < 0.05. * * р < 0.01 -significant differences from baseline. # р < 0.05 -significant differences from control group. ^ р < 0.05 -significant differences from 1st main group; SD = Standard deviation.    Pearson's correlation coefficients between hemodynamic parameters and biochemical parameters of the lacrimal fluid.

Experimental design, materials and methods
This data is collected from examinations of 165 patients (305 eyes) in the clinic of Tashkent medical academy. Patients had non-proliferative diabetic retinopathy (NPDR). Age ranged from 18 to 79 years, women were 94, men 71. The exclusion criteria were eye diseases such as glaucoma, inflammatory eye diseases, pigmented and other retinal dystrophies, retinal detachments, a period not earlier than 6 months after an eye injury or eye surgery, as well as severe somatic diseases such as kidney or liver failure, glucose-galactose malabsorption (GGM), hypertensive crisis.
Patients with NPDR were randomly allocated to receive standard treatment (hypoglycemic treatment, nootropil, statins, fenofibrats, angioprotectors) as the control group, in addition to the standard treatment daily tablets of EGb 761 (Tanakan, Beaufour Ipsen Industrie, Paris, France) 120 mg as the 1st main group, or daily endonasal electrophoresis of Tanakan 40 mg as the 2nd main group, within 10 days. The patients underwent anterior segment slit-lamp and fundus examinations using 60, 90D (Volk) lenses, Goldman three-mirror lens, and Mainster Standart fundus lens, the antioxidant activity of tears examinations, and Doppler ultrasound imaging of the eye.
The stages of DR were determined according to the severity scale of the Early Treatment Diabetic Retinopathy Study (ETDRS), the "gold" standard for a detailed assessment of the fundus condition in scientific studies worldwide. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) software version 23. P values < 0.05 were considered statistically significant.

Ethics statement
Permission of the National Ethics Committee of the Ministry of Health of the Republic of Uzbekistan No. 11 of 2.11.2010 All patients signed informed consent for treatment and examination

Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.