A process parameters dataset for the extrusion 3D printing of nutraceutical oral dosage forms formulated with monoglycerides oleogels and phytosterols mixtures

We report the parameter settings used in different 3D printing tests carried out to evaluate the production of nutraceutical oral forms by using mixtures of monoglycerides oleogels and phytosterols as printing materials. The printer employed was an ad-hoc extrusion 3D printing system adapted from a Prusa printer. The dataset here informed would serve as a starting point for the implementation of the 3D printing process to fabricate products using oleogels or printing materials with similar characteristics. This data is related to our recent research article entitled “Extrusion 3D printing of nutraceutical oral dosage forms formulated with monoglycerides oleogels and phytosterols mixtures” [1].


Data
The complete set of printing parameters for the extrusion 3D printing of nutraceutical oral forms formulated with different mixtures of monoglycerides oleogels and phytosterols are shown in Table 1. The information includes: Mixture: 8 different mixtures formulated using 10 or 20 %wt of monoglycerides in high oleic sunflower oil (oleogel) and ratios between 20 and 50 %wt of phytosterols/oleogel were tested. The mixtures were coded according to the monoglycerides concentration and the phytosterols/oleogel ratio (e.g., M10-20 contains 10 %wt of monoglycerides and 20 %wt of phytosterols/oleogel). Syringe temperature set-point (T set ). Measured syringe temperature (T s ). Measured nozzle temperature (T n ). Ambient temperature (T amb ).
Specifications Table   Subject Process Chemistry and Technology Specific subject area 3D printing of nutraceuticals Type of data Table  Image  How data were acquired Printing was performed in an ad-hoc extrusion 3D printer adapted from a Prusa with Repetier-Host (V2.0.5) [2] software for parameter settings. Image acquisition by digital camera.
Temperatures were recorded using a digital thermometer. Data format Raw Parameters for data collection Normal printing conditions Description of data collection Through the printer software (Repetier Host V2.0.5, [2]) the following variables were registered: Syringe temperature set-point, first layer extrusion width, filament diameter, in fill percentage, shell thickness, flow percentage, z-hop, layer thickness, first layer thickness, printing speed, infill pattern, and infill overlap. It was also registered if the cooling fan was on, the use of Peltier as This article provides data for the first time for the setting conditions required in an extrusion 3D printer system to successfully print oral forms in which the printable material consists of molten mixtures of monoglycerides oleogels and phytosterols. The provided information shows the relationship between some printing parameters, the gel point of printing materials, and the printability under these setting conditions. This dataset could be used to assist extrusion 3D printer users in the setting of printing parameters, which need to be adapted to the specific material properties of the particular process. These data can be used to explore different printing settings that allow to optimize the process of obtaining nutraceutical oral forms by using monoglycerides oleogels and higher phytosterols ratio or oleogels incorporating other different liposoluble molecules. The dataset here informed would serve as a starting point for the implementation of the 3D printing process to fabricate products using oleogels or printing materials with similar characteristics. These data confirm the feasibility of applying 3D printing technologies focused on food and nutraceutical products, which is a very recent field of investigation.
I.M. Cotabarren et al. / Data in brief 28 (2020) 104805 Table 1 Process parameters settings and oral dosage pictures for de extrusion 3D printing of mixtures containing monoglycerides oleogels and phytosterols.
Mixture Tset ( C) T n ( C) T s ( C) T amb ( C) T P ( C) Mass  Build platform temperature (T P ).
Mass of the successful printed oral dosage forms. First layer extrusion width: it establishes the width of the line of deposited material as a percentage (100% default setting). Filament diameter: in a commercial Prusa it is the diameter of the used polymer filament. Since this is an ad-hoc extrusion printer, this value was set according to the amount of material that is pushed out of the syringe in each motor step. Infill density percentage: this parameter states how much material is to be printed in the inner lines of each layer; the higher the infill density is, the more lines the extruder will print in each layer. Shell thickness: it is the width of the outer perimeter printed in each layer. Flow percentage: refers to how much material is to be extruded during the printing process. Z-hop: this is the vertical distance that the nozzle retracts when moving without extruding material. It prevents or reduces the scratching of the object surface.
Layer thickness: defines the height of each layer of the deposited material. First layer thickness: defines the height of the first layer of the deposited material.
Printing speed: it is the nozzle displacement velocity. Infill pattern: refers to the movements described by the nozzle when printing the interior paths of each layer. It can take two settings: linear, which means that the interior paths are longitudinal lines starting at one side of the object; or concentric, in which the nozzle describes concentric lines starting from the outer perimeter of the object. Infill overlap percentage: it is the overlap between the consecutive infill lines expressed as percentage.
Fan speed: it represents the cooling fan operation. It was either set OFF or ON (for a certain time) during the printing process. For example, "ON 30% of printing" indicates that fan was running during 30% of the time the printing last. In all the specified cases, the fan was set ON during the last part of the process. Type of nozzle: 3 different nozzles were tested, each one presenting different dimensions (see Cotabarren et al. [1] for more detail).
Peltier use: it indicates either if the build platform was refrigerated or not by a Peltier system. Picture: images for all the successful printed oral forms are included. To further illustrate the printing process, several images for the non-successful printed oral forms are also included.

Experimental design, materials, and methods
The printing procedure used to obtain the solid forms consisted of the following steps: