Morphometric and hemodynamic parameter dataset for coronary artery aneurysms caused by atherosclerosis

In comparison with intracranial aneurysm, there are relatively few investigations of coronary artery aneurysms (CAA). Coronary atherosclerosis is the first cause of CAA; therefore, it is necessary to providing as many details of clinical CAA caused by atherosclerosis as possible. The aim of the data is to provide morphometric and hemodynamic parameters of CAAs caused by atherosclerosis, as well as the demographics of patients with CAAs. Various morphometric parameters were obtained from the reconstructed epicardial coronary arterial trees of 61 patients while multiple hemodynamic parameters were determined from their computed flow fields. The data classified the CAAs into 4 types. All subjects in each group are listed in this data article. This data set support the main findings presented in the research article (Fan et al., 2019).


Data
The dataset presented in this article describes morphometric and hemodynamic parameters in epicardial coronary arteries of patients with CAAs caused by atherosclerosis. And it also provides the demographics of the CAA study population. There are 61 patients with 80 CAAs, which includes 10 CAAs of type I, 18 CAAs of type II, 29 CAAs of type III and 23 CAAs of type IV. Table 1 and Table 2 list the demographics (e.g., age, myocardial ischemia, diabetes mellitus) of 61 patients. Table 3 and Table 4 list the morphometric parameters (i.e., L/W, L chord =L arc , 4 and Mean Dfit of aneurysm) for type I-IV CAAs. Table 5 and Table 6 list hemodynamic parameters (i.e., SAR-OSI and SAR-TAWSS) for type I-IV CAAs.

Materials
The experiment shows the demographic data for 61 patients (patient numbers, P1eP61) with CAAs, who underwent coronary CT angiography (CTA) of the coronary arteries at the Beijing Anzhen Hospital, Beijing, China. A total of 80 coronary artery aneurysms (CAA number, C1eC80) were identified among these 61 specific patients. Multiple morphometric parameters are also defined. The study was approved by the Institutional Review Board (IRB) for the Beijing Anzhen Hospital, which conforms with the declaration of Helsinki.

Methods
Here, CAAs caused by atherosclerosis are divided into four groups in this data set. As the presence of a coronary artery bifurcation is the main major risk factor for CAAs followed by high aneurysm shape index (L/W, where L and W refer to the aneurysm length and maximum diameter, respectively); the characteristics of CAAs are grouped into type I (L/W ! 2 and CAA covering a bifurcation), type II (L/ W < 2 and CAA covering a bifurcation), type III (L/W ! 2 and CAA in one vessel), and type IV (L/W < 2 and CAA in one vessel).

Demographic data
General medical examinations, including medical history collection, blood pressure measurement, blood sampling, and urine analysis were performed. ST segment elevations as well as hyperacuity T waves were used for determination of myocardial ischemia. (Hf-800b semi-automatic blood biochemical analyzer, HLIFE kangyu medical, ji nan, China). Demographics of the study population, including age, sex, myocardial ischemia, hypertension, hyperlipidemia, diabetes mellitus, smoking, blood pressure, fasting blood glucose, triglycerides, cholesterol concentrations, and body mass index are listed in Tables 1 and 2. 1. LDL: low density lipoprotein 2. HDL: high density lipoprotein 3. BMI: body mass index 4. ##: unknown information 5. TC: total cholesterol

Morphometric data
Similar to previous studies [2,3], the Coronary CTA was performed through three CT scanners (i.e., 256-row detector CT scanner [Revolution CT, GE Healthcare, Milwaukee, USA], 320edetector row [Aquilion One; Toshiba, Otawara, Japan], or dual-source [Somatom Definition Flash; Siemens, Forchheim, Germany] CT). All studies were of diagnostic image quality with optimal contrast enhancement and no substantial motion artifacts. All digitized data were imported into the MIMICS Innovation Suite platform (Materialise Company, Belgium) for 3D geometry reconstruction. Morphometric data of the epicardial coronary arteries with the CAA, i.e., L/W, L chord =L arc , 4 and Mean Dfit of aneurysm were extracted based on the coronary CTA in each aneurysm (detailed definitions as follows).  The morphometric parameters for type I and II CAAs, which includes 10 type I CAAs and 18 type II CAAs, are listed in Table 3. The morphometric parameters for Type III and IV CAAs, which includes 29 type III CAAs and 23 type IV CAAs, are listed in Table 4.

Hemodynamic data
Based on morphometric data, geometrical models were meshed using the ANSYS ICEM software (ANSYS Inc., Canonsburg, USA). The Navier-Stokes and continuity equations were solved using a finite volume solver, FLUENT (ANSYS Inc., Canonsburg, USA), as in previous studies [2,3]. Three cardiac cycles were required to achieve convergence for the transient analysis. A constant time step was employed, where Dt ¼ 0.01 s with 84 total time steps per cardiac cycle. The aortic pulsatile pressure wave was applied to the inlet of epicardial coronary arterial tree [2]. The resistance boundary condition was assigned to each outlet [2].
The time-averaged wall shear stress (TAWSS) and the oscillatory shear index (OSI) were obtained from the computed flow fields. From the data, we also computed SAR-TAWSS [4,5] and SAR-OSI [6,7] within the CAA region (detailed definitions as follows).
The hemodynamic parameters for type I and II CAAs, which includes 10 type I CAAs and 18 type II, are listed in Table 5. The hemodynamic parameters for type III and IV CAAs, which includes 29 type III CAAs and 23 type IV CAAs, are listed in Table 6.