Data on a single oral dose of camu camu (Myrciaria dubia) pericarp extract on flow-mediated vasodilation and blood pressure in young adult humans

This data article describes the flow-mediated vasodilation (FMD) responses, represented by changes in arterial diameter, and blood pressure changes in young adults after a single oral dose of camu camu (Myrciaria dubia) pericarp extract or placebo (cross-over design). Ten healthy men and 10 healthy women participated in this study. Ultrasonic diagnostic equipment was used to monitor arterial diameter changes, indicative of FMD, for 110 s after the administration of the camu camu extract or placebo. In addition, the systolic and diastolic blood pressure values were recorded.


Specifications
The brachial artery was monitored using ultrasonic diagnostic equipment, and the diameter was calculated. In addition, blood pressure was assessed.

Experimental features
A cross-over design was utilized. The camu camu extract/placebo was administered under conditions of dietary restrictions to avoid confounding.

Data source location
Abashiri, Japan Data accessibility The data are supplied with this article.

Value of the data
The data provide insights into the effect of camu camu pericarp extract on blood flow-mediated vasodilation and blood pressure.
The data can be used as a reference for comparisons with other foods that affect flow-mediated vasodilation and blood pressure.
The data describe a valuable and searchable functional food resource and can be used for future functional food studies.

Data
Flow-mediated vasodilation (FMD), which is the dilation response of the artery to the shear stress of blood flow, can be represented by the changes in brachial arterial diameter after an increase in blood flow. In clinical medicine and functional food studies, FMD measurements serve as a noninvasive method to study endothelial function [1][2][3]. The changes in arterial diameter after the administration of camu camu pericarp extract or a placebo are shown in Figs. 1 and 2. The arterial diameter values that were used to generate the line graphs in Fig. 1 are presented in Table 1. The blood pressure data recorded are shown in Table 2.

Participants
Twenty healthy students (10 men and 10 women; age range, 18-28 years) from the Hokkaido Okhotsk Campus of the Tokyo University of Agriculture were recruited in July 2017. Individuals with a history of hypertension, diabetes mellitus, or dyslipidemia were excluded because of the potential effects of these conditions on endothelial function. The study protocol was approved by the Tokyo University of Agriculture Committee of Human Subject Research Ethics. Informed consent was obtained from all participants.

Materials
The extract was prepared by stirring dried camu camu pericarps (1.5 kg) in two-fold volume of 50% ethanol for 2 h. The solution was filtered using filter paper, and the filtrate was collected. The filtered residue was subjected to a second round of ethanol extraction with same volume of 50% ethanol. The filtrates from the first and second rounds of ethanol extraction were pooled, and the ethanol was removed by evaporation; the filtrate was then freeze-dried. The freeze-dried powder was encapsulated into soft gelatin capsules (25 mg in each capsule) (Matsuya, Osaka, Japan). Three capsules containing the camu camu extract comprised a single dose; whereas, three soft capsules containing 25 mg of water each were administered as the placebo. The food restriction protocol involved the use of cereal (Flugra, Calbee, Tokyo, Japan) for meals.

Food restriction protocol and FMD measurement
The data were collected at the Hokkaido Okhotsk Campus of the Tokyo University of Agriculture between August and September 2017. By applying a cross-over design, each participant was randomly administered a single dose of the camu camu pericarp extract or water (placebo) in a soft capsule. The second dose was administered more than a week later. The food restriction protocol and FMD were assessed using ultrasonic diagnostic equipment (LOGIQ P6, GE Healthcare, Little Chalfont, UK), as previously reported [1]. Arterial diameter was calculated using the FMDscope software (Media Cross Co. Ltd, Japan). Blood pressure was measured using an electronic sphygmomanometer (ES-P2000, Terumo, Tokyo, Japan).