Data on expression of genes involved in estrogen and progesterone action, inflammation and differentiation according to demographic, histopathological and clinical characteristics of endometrial cancer patients

Endometrial cancer is the sixth most common cancer in women worldwide. It is associated with aberrant actions of steroid hormones, estrogens and progesterone, but also with enhanced inflammation and reduced cellular differentiation. Here, we show data on demographic and histopathological characteristics of 51 patients with endometrial cancer, together with data on correlations between the expression of 38 genes involved in estrogen and progesterone actions, inflammation and differentiation, and demographic characteristics. We also show data on changes in gene expression of these 38 genes according to histopathological and clinical characteristics of these patients. This article includes data referenced in the manuscript entitled »STAR and AKR1B10 are down-regulated in high-grade endometrial cancer by Sinreih et al. (in press) [1].

Data accessibility The statistically analyzed data is available within this article and the raw expression data may be provided upon request.

Value of the data
Data on correlations between the expression ratios of these 38 genes and demographic characteristics may be helpful for explanation of different etiological factors identified in epidemiological studies.
Data on changes in the expression ratios of these 38 genes according to histopathological and clinical data may lay foundation for further investigations of individual players of the individual pathophysiological processes.

Data
We provide data on demographic, histopathological and clinical characteristic of 51 endometrial cancer patients treated at the University Medical Centre Ljubljana, at the Division of Gynaecology and Obstetrics. Demographic (age, body mass, BMI, menopausal status, parity), histopathological and clinical data (histological type and grade of tumor, depth of myometrial invasion, presence of lymphovascular invasion, FIGO stage) ( Table 1) together with data on statistical analysis of gene expression ratios (Tables 2-11) are included. The study was approved by the National Medical Ethics Committee of the Republic of Slovenia.

Gene
Age Body mass BMI Age at menopause Parity  Table 4 Correlations between expression of genes involved in progesterone biosynthesis and action and demographic characteristics of endometrial cancer patients. Spearman's rho correlation coefficient (Rho) and 2-tailed significance (p) and adjusted significance (Adj. p) and N number of endometrial cancer cases are shown. * Correlation is significant at the 0.05 level (2-tailed).  Table 6 Correlations between expression of genes involved in PGF2α biosynthesis and retinoic acid metabolism and demographic characteristics of endometrial cancer patients. Spearman's rho correlation coefficient (Rho) and 2-tailed significance (p) and adjusted significance (Adj. p) and N number of endometrial cancer cases are shown. n Correlation is significant at the 0.05 level (2-tailed), ** Correlation is significant at the 0.001 level (2-tailed).

M. Sinreih et al. / Data in Brief 12 (2017) 632-643
Forty-six (92.0%) of the 50 patients with the relevant data had at least one full-term pregnancy, four (8.0%) had none. Information for menopausal status was also available for 50 patients, with 38 (76.0%) post-menopausal and 12 (24.0%) pre-menopausal. The minimum age at the last menstruation  Changes in expression were tested using Mann-Whitney nonparametric tests for two-group comparisons, and Wilcoxon nonparametric W tests. Corrections for multiple testing were performed according to Benjamini and Hochberg [7]. Asymptotic 2-tailed significance (p) is shown.   was 40 years, and the maximum was 65 years, with the mean of 52.34 years (SD, 4.54 years). The longest post-menopausal time before analysis was 33.6 years. The Cancer Registry of the Republic of Slovenia was searched for the vital status of these 51 patients. The cut-off point was June 20, 2016, at which date 36 (70.6%) of these patients were still alive, and 15 (29.4%) were dead. The mean age at death was 75.36 years (SD, 9.30 years), with the minimum age at death of 57.05 years, and maximum age of 86.44 years. Eight patients (15.7%) died of cancer: four (7.8%) of uterine cancer, one of ovarian cancer, one of kidney cancer, one of malignant melanoma of the skin, and one of glioblastoma (2.0%, for each). Three patients (5.9%) died of chronic ischemic heart disease, one of atherosclerotic arteries of the extremities, one of benign meningeal neoplasm, and one of infection and inflammatory reaction due to an internal joint prosthesis (2.0%, for each). Morbid obesity with alveolar hypoventilation resulted in the death of one of the patients (2.0%).

Statistical analysis
The correlations between the ratios for expression of 38 genes in tumor/ adjacent control tissue and demographic parameters were evaluated by calculating Spearman's correlation coefficient rho (Tables 2-6). The statistical significant changes in the ratios for expression of 38 genes in tumor/ adjacent control tissue with regard to histopathological and clinical characteristics were tested using the Mann-Whitney test and the Wilcoxon W test, followed by Benjamini and Hochberg corrections for multiple testing [7] (Tables 7-11). help with preparation of Table 1. The contribution of Dr. Tina Šmuc and Dr. Neli Hevir with the published gene expression data is also acknowledged. This study was supported by a grant J3-5510 to T.L.R. from the Slovenian Research Agency.

Transparency document. Supporting information
Transparency data associated with this article can be found in the online version at http://dx.doi. org/10.1016/j.dib.2017.04.050.