Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism

The data presented in this article are related to the review article entitled ‘Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis’ (Saavedra-Garcia et al., 2017) [24]. Here, we have matched the DAF-16/FOXO3 downstream genes with their respective human orthologues and reviewed the roles of these targeted genes in FA metabolism. The list of genes listed in this article are precisely selected from literature reviews based on their functions in mammalian FA metabolism. The nematode Caenorhabditis elegans gene orthologues of the genes are obtained from WormBase, the online biological database of C. elegans. This dataset has not been uploaded to a public repository yet.


Specifications
Cell Biology More specific subject area Lipid metabolism Type of data Value of data The dataset shows the extensive overlap in the signaling pathway and molecules involved in the FOXO3-FOXM1 axis and FA metabolism. The assessment of this interaction can be of value for research group from related fields.
The dataset allows integration of researches in oncology and metabolic diseases. The dataset opens up new approaches to study the roles of FOXO3-FOXM1 axis and FA metabolism in breast cancer initiation, progression and metastasis and drug resistance.
These data also be useful for researches in all cancer types where lipid and energy metabolism is implicated.

Data
Based on literature reviews, we observed that the DAF-16 is the C. elegans orthologues of mammalian forkhead box (FOX) proteins, FOXO3 and FOXM1, and also the primary factor essential for enhancing the expression of gene networks involved in regulation of fatty acid (FA) metabolism [1,5,9,24],25]. The dataset of this article provides information of the genes that are overlapped in cellular pathways involved in both FOXO3-FOXM1 axis and FA metabolism [4, 13,18,35]. From Amrit et al., we selected a list of FA metabolism regulatory genes that are downstream of DAF-16/FOXO3 [1]. To better understand the roles of FOXO3-FOXM1 axis in FA metabolism, we then matched the genes with their respective human orthologues using WormBase (www.wormbase.org), and their roles in lipid and energy metabolism are summarized in Table 1. Table 1 List of Human homologues and orthologues of lipid-metabolic genes identified as DAF-16 and/or TCER-1 targets through RNA-Seq by [1] and their potential functions in lipid metabolism.

fasn-1
Fatty acid synthase (FASN) The major regulatory enzyme that mediates the de novo synthesis of saturated FAs from acetyl-CoA and malonyl-CoA [2]. Human orthologues (from WormBase) [27] Role in lipid and energy metabolism mboa-2 Diacylglycerol O-acyltransferase (DGAT) 1 One of 2 enzymes that catalyze the final step in triacylglycerol (TAG) synthesis in which diacylglycerol (DAG) is covalently bound to long chain fatty acyl-CoAs [26].
The second enzymes that catalyze the final reaction in the synthesis of TAG [28].

ech-1.2
Hydroxyacyl-CoA The tri-functional protein that catalyzes the last three steps of mitochondrial β-oxidation of LCFAs [22].

ACOX2
The key regulatory enzyme of the β-oxidation pathway 2 for side chain oxidation of cholesterol [15,33].

hacd-1
Hydroxyacyl-coenzyme A dehydrogenase (HADH) An enzyme functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the β-oxidation pathway. Its enzymatic activity is higher with medium-chain-length FAs [31].

Acknowledgements
Lavender Yuen-Nam Fan is a PhD student and research assistant supported by Imperial College IC Trust. Paula Saavedra-García is a post-doctoral research associate supported by the Medical Research Council (MRC) of UK (MR/N012097/1). Eric W.-F. Lam's work is supported by MRC (MR/N012097/1), CRUK (A12011) and Breast Cancer Now (2012MayPR070; 2012NovPhD016).

Transparency document. Supplementary material
Transparency data associated with this article can be found in the online version at http://dx.doi. org/10.1016/j.dib.2017.02.055.  Human orthologues (from WormBase) [27] Role in lipid and energy metabolism fat-2 Fatty acid desaturase 2(FADS2) A delta-12 fatty acyl desaturase that catalyzes the formation of double bond between defined carbons of fatty acyl chain [10].

acs-2
Members of Acyl-CoA synthetase family, such as acyl-CoA Synthetase Short-Chain Family member (ACSS) 1, ACSS2 and ACSS3 Enzymes predicted to catalyze the conversion of acetate to acetyl-CoA in order for it to feed to the tricarboxylic acid (TCA) cycle to produce ATP [27]. elo-1, elo-2 Polyunsaturated fatty acid (PUFA) elongases, such as Elongation of very long chain fatty acids protein 1 (ELOVL1) Microsomal enzymes involved in VLCFA elongation during increased β-oxidation [7,21].