Data for outcomes of acute hospital administration of amiodarone and/or lidocaine in shockable patients presenting with out-of-hospital cardiac arrest

The data presented in this article are related to the research article entitled “Acute Hospital Administration of Amiodarone and/or Lidocaine in Shockable Patients Presenting with Out-of-hospital Cardiac Arrest: A Nationwide Cohort Study” (C.H. Huang, P.H. Yu, M.S. Tsai et al., 2016) [1]. The data contains the information of co-morbidities coding from ICD-9 CM codes and specific difference in requirement between medical centers and non-medical centers in resuscitation. Univariate and multivariate logistic regression analysis for factors related to the outcome of survival to ICU admission and survival to hospital discharge are included in the data set. The data also contains bootstrap sensitivity analysis of the logistic regression model for survival to ICU admission and hospital discharge outcomes in out-of-hospital cardiac arrest. Subgroup analysis of epinephrine dosage related to outcome of one-year survival is shown.


Subject area
Biology More specific subject area

Acute cardiac care
Type of data Tables  How data was  acquired Data analysis for national health insurance database Data format Analyzed Experimental factors Data are analyzed to figure out the outcomes related variables Experimental features Retrospective, observational, and nationwide population-based cohort study of patients with non-traumatic cardiac arrest Data source location A nationwide cohort study in Taiwan Data accessibility The analyzed data is with this article.

Value of the data
The data provide information the ways of coding co-morbidities and hospital levels in the resuscitation study. The short term outcomes of survival to hospital admission, intermediate outcome of survival to hospital discharge are important in cardiac arrest patient.
The data provides the information so that the effects of specific intervention can be comprehensively figured out and compared.
Subgroup analysis of patients with different dosage of epinephrine used in resuscitation show the interaction with effects of anti-arrhythmic agents.

Data
The data contains the information of co-morbidities coding from ICD-9 CM codes and specific difference in requirement between medical centers and non-medical centers in resuscitation as shown in Tables 1 and 2. Univariate and multivariate logistic regression analysis for factors related to  the outcome of survival to ICU admission and survival to hospital discharge are included in the data  set Tables 3a and 3b. The data also contains bootstrap sensitivity analysis of the logistic regression model for survival to ICU admission and hospital discharge outcomes in out-of-hospital cardiac arrest as shown in Table 4. Subgroup analysis of epinephrine dosage related to outcome of one-year survival is shown in Table 5.

Experimental design, materials and methods
Medical records/reports accruing between years 2004 and 2011 were retrieved from the Taiwan National Health Insurance Research Database (NHIRD) for review. This repository releases anonymous secondary data for research purposes and houses all claims data from the National Health Insurance (NHI) program in Taiwan. Launched in 1995, the NHI provides coverage for 499% of the entire Taiwanese population of 23.74 million [2]. The database details all patient demographics and orders for medical care. Taiwan's NHI Bureau is responsible for comprehensive review of medical records and examination reports [3]. Disease diagnoses are coded according to the International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM). The study protocol was approved by the National Taiwan University Hospital Research Ethics Committee.

Study design
This retrospective, observational, and nationwide population-based cohort study of patients with non-traumatic cardiac arrest was designed to investigate the impact of amiodarone and lidocaine usage on survival outcomes. Subjects were selected entirely from the NHIRD, all undergoing DC shock and cardiopulmonary resuscitation during short emergency room stay between January, 2004 and December, 2011. Grounds for exclusion were stipulated as follows: 1) age o 18 years, 2) traumarelated event, 3) emergency room stay 46 h, or 4) non-level one triage. Patients were categorized and triaged into level-one if vital signs were extremely unstable and needed immediate resuscitation when presented to emergency department. Any known recipients of lidocaine or amiodarone (oral or intravenous) within 1 year previously were also excluded to minimize therapeutic interference. Patients were followed from cardiac arrest index date to 1-year survival status or death. Analysis was based on data from emergency rooms and hospitalization and not from ambulance or from resuscitation on the scene in the study [1].