Current Biology
Volume 24, Issue 15, 4 August 2014, Pages R693-R695
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Limited Proteolysis: DisRUPting Proteasomal Inhibition

https://doi.org/10.1016/j.cub.2014.06.056Get rights and content
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Summary

The 26S proteasome is a protease complex that completely degrades substrate proteins marked with a chain of ubiquitins, but is also able to perform endoproteolytic cleavage. A new study now demonstrates that regulated ubiquitin–proteasome-dependent processing ameliorates proteasomal inhibition.

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