Editorial overview
Inhibition: synapses, neurons and circuits

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Gord Fishell is the Julius Raynes Professor of Neuroscience and Physiology at NYU School of Medicine and the associate director of the NYU Neuroscience Institute. His laboratory is interested in using molecular genetic approaches to study how cortical interneuron diversity in mammals is generated and how specific subtypes of these neurons functionally integrate into the cerebral cortex during development. He was briefly an assistant professor at the Rockefeller University and then took a

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Gord Fishell is the Julius Raynes Professor of Neuroscience and Physiology at NYU School of Medicine and the associate director of the NYU Neuroscience Institute. His laboratory is interested in using molecular genetic approaches to study how cortical interneuron diversity in mammals is generated and how specific subtypes of these neurons functionally integrate into the cerebral cortex during development. He was briefly an assistant professor at the Rockefeller University and then took a position in the NYU's Developmental Genetics program at the Skirball Institute. Since establishing his own laboratory, Dr. Fishell has studied how GABAergic interneurons are specified and integrate into the brain. Present work in the laboratory centers around examining how laminar and areal position within the cerebral cortex influences the connectivity of particular cortical interneuron subtypes. This work has led his laboratory to study the mechanisms by which interneurons establish their obligate contacts with the principal excitatory pyramidal neurons, a process that increasingly appears to rely on local activity-dependent cues.

Gábor Tamás completed his PhD with Peter Somogyi and identified the number and position of synapses between neocortical neurons. His group found that neurogliaform cells elicit slow inhibition in the cortex and showed that apart from being inhibitory, axo-axonic cells might serve as the most powerful excitatory neurons. His current work is concerned with in depth molecular analysis of identified interneurons and subsequent functional analysis of novel marker genes at the cellular and network level in human and rodent cortices.

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