Cell
Volume 151, Issue 6, 7 December 2012, Pages 1256-1269
ArticleThe Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes
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Graphical Abstract
Highlights
► Syntaxin 17 is present on completed autophagosomes but not isolation membranes ► Stx17 is required for autophagosomal fusion with the endosome/lysosome ► Stx17 has two tandem transmembrane domains containing glycine zipper-like motifs ► The hairpin-like transmembrane structure is required for autophagosomal targeting
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Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
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Present address: Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
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