Cell
Volume 125, Issue 7, 30 June 2006, Pages 1225-1227
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Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration

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Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.

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