Cancer Cell
Volume 21, Issue 3, 20 March 2012, Pages 297-308
Journal home page for Cancer Cell

Perspective
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

https://doi.org/10.1016/j.ccr.2012.02.014Get rights and content
Under an Elsevier user license
open archive

Cancer metabolism has long been equated with aerobic glycolysis, seen by early biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures of cancer cells are not passive responses to damaged mitochondria but result from oncogene-directed metabolic reprogramming required to support anabolic growth. Recent evidence suggests that metabolites themselves can be oncogenic by altering cell signaling and blocking cellular differentiation. No longer can cancer-associated alterations in metabolism be viewed as an indirect response to cell proliferation and survival signals. We contend that altered metabolism has attained the status of a core hallmark of cancer.

Cited by (0)