Cancer Cell
Volume 14, Issue 6, 9 December 2008, Pages 431-433
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The Aneuploidy Paradox in Cell Growth and Tumorigenesis

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Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.

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