Cancer Cell
Volume 30, Issue 6, 12 December 2016, Pages 834-835
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S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver

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A recent study reports a novel small molecule inhibitor of MCL-1 with efficacy in killing MCL-1-dependent cancer cells in vitro and in vivo. With the advent of S63845, the targeting of BCL-2, BCL-XL, and MCL-1 is now possible in vivo, but optimal clinical use is yet to be determined.

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