Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
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Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgments
This work was partly supported by JSPS KAKENHI (20K05743 to T.S.; 16H05098 to H.N., Y.I-T., T.S.; 18K11014 to Y.I-T., T.S.; 19K07314 to Y.I-T.; 19K05710 to N.K.), MEXT Grant-in-Aid for Scientific Research on Innovative Areas (JP15H05942 “Living in Space” to H.N.; JP17H06049 “Willdynamics” to Y.I-T,), Japan Foundation for Applied Enzymology (16H007 to T.S.) and Toray Industries, Inc. This work is also supported by the grant of collaborative research between University of Tsukuba and Toyota Motor
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