Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect☆
Graphical abstract
A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent.
Section snippets
Acknowledgement
We are thankful to both the reviewers for number of valuable suggestions, the management of Zydus Group for the encouragement including Dr. B. B. Lohray and Dr. V. B. Lohray, analytical department for analytical support, Mr. Amol Dhawas, Mr. Pravin Kadam for synthesizing some of the intermediates, Mr. Sandeep Shegade and Mr. Pankaj Makadia for the help in the preparation of the manuscript.
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2018, Biochemical PharmacologyCitation Excerpt :In principle, CB1 antagonists could therefore promote hair growth, and a study was done on the effect of the CB1 antagonist Rimonabant and a close analogue on hair growth. Modest effects on hair growth were observed with the analogue, but not with Rimonabant itself [11], and further research is needed to critically evaluate the potential CB1 antagonists as hair growth stimulators. The effect of TRPV1 stimulation on hair growth has also been investigated.
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ZRC Communication # 234.
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Present address: Department of Chemistry, The University of Warwick, United Kingdom.
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Present address: Department of Chemistry, University of Cambridge, United Kingdom.