Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents☆
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Acknowledgments
Instrumentation facilities from SAIF, CDRI are gratefully acknowledged. S.G. thanks CSIR, New Delhi, for providing a Junior Research Fellowship. A.K.M. thanks DST, New Delhi for Ramanna fellowship.
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2018, European Journal of Medicinal ChemistrySynthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiosemicarbazones
2016, European Journal of Medicinal ChemistryCitation Excerpt :Thiosemicarbazone derivatives containing monosaccharide moiety have shown the remarkable anti-microorganisms and antioxidant activity both in vivo and in vitro [23,24]. Some articles in the past reported about the synthesis of substituted aromatic aldehyde/ketone N-(per-O-acetylated glucopyranosyl)thiosemicarbazones [11,23,24–27]. These compounds have been synthesized by reaction of N-(per-O-acetyl-β-d-glycosyl)thiosemicarbazides with the corresponding carbonyl compounds, but the thiosemicarbazones containing simultaneously monosaccharide and isatin moieties have not been reported yet.