Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring
Graphical abstract
Structure activity relationship studies of the A-ring on the benzopyran scaffold.
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2021, BiochimieCitation Excerpt :For ERα, the template structures chosen to build the model were 2JFA [29] and 5FQP [30], both solved when the receptor is in the inactive conformation. In relation to ERβ, the structures used were 5TOA [31], 2I0G [32], 1QKM [33], 1U9E [34], 2GIU [35], 1X76 [34] and 1ZAF [36]. All the seven structures are in an active conformation.
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