Archival ReportAtrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease
Section snippets
Subjects
Magnetic resonance imaging (MRI) scans were retrieved from the Open Access Series of Imaging Studies (OASIS) database (26; http://www.oasis-brains.org) and included 211 healthy individuals (20–94 years) as well as 28 subjects with clinically manifest AD (CDR = 1, Mini Mental State Examination [MMSE] = 21.7 ± 3.8, age = 77.8 ± 7.0) and 69 subjects with very mild/questionable AD (vmAD; CDR = .5, MMSE = 25.6 ± 3.5, age = 76.2 ± 7.2). Demographics and global neuropsychological profiles of the
Age-related GM Loss Within the BFCS
Results of the voxel-wise linear regression analysis between age and GM volume of the BFCS are shown in Figure 1. Significant age-related reductions of bilateral GM volume within the BFCS were detected throughout the ROI, including the vertical (Ch2) and horizontal (Ch3) limb of the DB as well as anterior, intermediate, and posterior parts of the NBM (Ch4). Peak effects of age-related volume decline are listed in Table S2 in Supplement 1. They corresponded to anterior lateral (Ch4al), medial
Discussion
Here we demonstrate age-related decline of BFCS GM volume that begins in early adulthood and is aggravated in advanced age. The effects of age on BFCS GM volume were preserved, even when effects of age on overall cerebral GM volume were taken into account. Although there is only slight evidence from structural in vivo neuroimaging studies so far (18), age-related decreases of BF cholinergic neuron number and size starting early in adult life have been reported by a range of postmortem studies
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