Archival ReportA β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress
Section snippets
Animals and Housing
Male c57BL6/J mice (Jackson Laboratories, Bar Harbor, Maine) (8–10 weeks old) and CD1 retired breeder mice (Charles River, Wilmington, Massachusetts) were housed in the The University of Texas Southwestern Medical Center (UTSW) vivarium in a temperature-controlled environment (lights on: 04:00-16:00) with ad lib access to water and standard chow (4% fat diet #7001, Harlan-Teklad, Madison, Wisconsin) or high-fat diet (HFD) (42% kcal from fat, TD.88137, Harlan-Teklad) as noted. Melanocortin 4
Metabolic Effects of Chronic Social Defeat Stress
Following 10 days of CSDS, wild-type C57BL/6 male mice were tested for social interaction and randomized into two groups with equivalent interaction scores. The mice received either regular chow or a Western-style diet that is high in fat and cholesterol (high-fat diet). In the first set of experiments, we characterized the effect of CSDS on food intake and body weight regulation in chow-fed animals. Mice initially lost weight during the first days of the CSDS paradigm; however, beginning at
Discussion
Determining the effects of chronic stress on the regulation of feeding and body weight is of critical importance because of the well-known association between psychiatric disorders and metabolic diseases, as outlined above. The current findings provide a molecular and neurobiologic model that explains, in part, the link between altered mood and metabolic status. This model, and the extensive characterization provided here, can now be used in future studies to further investigate the underlying
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