Original articleFunctional Magnetic Resonance Imaging Study of Regional Brain Activation During Implicit Sequence Learning in Obsessive–Compulsive Disorder
Section snippets
Subjects and Clinical Assessments
Written informed consent was obtained from all subjects before enrollment; this study was approved by the Partners Human Research Committee. Data are reported from 12 subjects with OCD and 12 HC subjects who were group-matched for gender (8 women, 4 men), age [(mean ± SD) OCD: 28 ± 5.66 years; HC: 27 ± 6.61 years; t(22) = .40, p = .69], and years of education [OCD: 15.33 ± 1.56 years; HC: 16.67 ± 2.46 years; t(22) = –1.58, p = .13]. All subjects were right-handed (Oldfield 1971) and were
Subject and Data Selection
Sixteen OCD and 40 HC subjects were initially tested. Six HC and two OCD subjects were excluded because of scanner errors. Four HC and one OCD subject were excluded because of explicit contamination (> 6 consecutive correct responses on the debriefing task). One OCD subject was excluded because of excessive motion. Twelve of the remaining 30 HC were selected, blind to individual fMRI or other behavioral data, to best match the age, gender, and educational level of subjects in the OCD group.
Discussion
These findings represent the third report, in entirely independent samples, showing aberrant hippocampal recruitment during implicit sequence learning in OCD versus healthy comparison subjects, in the absence of significant differences in behavioral indices of learning. This confirms prior findings and extends the results to a larger cohort of subjects, including both genders. Unlike the two previous reports, however, here we did not find a significant decrement in activation within right
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2022, Journal of Behavior Therapy and Experimental PsychiatryCitation Excerpt :However, a closer inspection of their data shows that in the intentional condition no differences were found between groups, consistent with the current results. Moreover, research into declarative, explicit memory performance has shown that OCD patients use declarative processes in procedural tasks, which partially or completely compensates behavioral deficits in implicit learning (Rauch et al., 1997; Rauch et al., 2007; for a review see; Ullman & Pullman, 2015). This raises the possibility that explicitly presenting the sequence to participants in our task reduced demands on procedural processes.
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2021, Journal of Behavior Therapy and Experimental PsychiatryCitation Excerpt :Since the selective mode cannot convey the full complexity of the underlying rule structure, it is prone to false inductions and consequent impairments in performance. In light of previous studies suggesting prominence of explicit processing mode in OCD (e.g., Rauch et al., 2007; Soref et al., 2018), a secondary goal of the present study was to explore whether the extent of this impairment would be different for the OCD as compared to the NPC participants. Demographic and clinical characteristics of the study samples are presented in Table 1.
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