2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish
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open access
Graphical abstract
Abbreviations
NAFLD
non-alcoholic fatty liver disease
TSG
2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside
NASH
non-alcoholic steatohepatitis
ROS
reactive oxygen species
OS
oxidative stress
NF-κB
nuclear transcription factor kappa
DCFH-DA
2’,7’-dichlorofluorescin diacetate
HCD
high cholesterol diet
NCD
normal cholesterol diet
dpf
days post fertilization
BMI
body mass index
TC
total cholesterol
TG
triglyceride
SOD
superoxide dismutase
MDA
malondialdehyde
NEFA
nonesterified fatty acids
HE staining
hematoxylin and eosin staining
RT-qPCR
reai-time quantitative PCR
fasn
fatty acid synthase
srebf1
sterol regulatory element binding protein 1
cpt1a
carnitine palmitoyltransferase 1a
pparab/PPAR-α
peroxisome proliferator-activated receptor alpha
pparg/PPAR-γ
peroxisome proliferator-activated receptor gamma
IKKβ
inhibitor kappa B kinaseβ
il6
interleukin 6
il1β
interleukin 1 beta
tnfa
tumor necrosis factor alpha
keap1
kelch-like ECH-associated protein 1
Nrf2
nuclear factor erythroid 2-related factor 2
HO-1
heme oxygenase 1
n-3 LCPUFA
n-3 long-chain polyunsaturated fatty acid
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
FFA
free fatty acid
Keywords
2,3,5,4'-Tetrahydroxystilbence-2-O-β-D-glucoside
Hepatic steatosis
Non-alcoholic fatty liver disease
IKKβ/NF-κB pathway
Keap1-Nrf2 pathway
High cholesterol diet
Larval zebrafish
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© 2020 The Author(s). Published by Elsevier Masson SAS.