Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume 1818, Issue 9, September 2012, Pages 2192-2201
Antimicrobial selectivity based on zwitterionic lipids and underlying balance of interactions
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Highlights
► Antimicrobial peptide (AMP) NK-2 binds more strongly to POPE than to POPC bilayer. ► Stronger binding to PE opposed by electrostatic peptide-lipid interactions. ► Binding selectivity arises from subtle balance of interactions. ► Selective binding is crucial for recognition of prokaryotic membranes. ► Understanding AMPs is important for development of new antibiotical drugs.
Keywords
Antimicrobial peptide
MD simulation
Selectivity
Membrane
Thermodynamic integration
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